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CP-226,269

Summary

CP-226,269 is a drug which acts as a dopamine agonist selective for the D4 subtype, which is used for researching the role of D4 receptors in the brain.[1][2]

CP-226,269
Identifiers
  • 5-fluoro-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole
CAS Number
  • 220941-93-5 ☒N
PubChem CID
  • 9796720
IUPHAR/BPS
  • 973
ChemSpider
  • 7972486 checkY
UNII
  • WX4CVT9DYH
ChEMBL
  • ChEMBL77395 checkY
CompTox Dashboard (EPA)
  • DTXSID70430875 Edit this at Wikidata
Chemical and physical data
FormulaC18H19FN4
Molar mass310.376 g·mol−1
3D model (JSmol)
  • Interactive image
  • n4ccccc4N3CCN(CC3)Cc2cc1cc(F)ccc1[nH]2
  • InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2 checkY
  • Key:PQOIDBZLMJMYCD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

References edit

  1. ^ Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC (May 1999). "D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia". Molecular Psychiatry. 4 (3): 235–46. doi:10.1038/sj.mp.4000522. PMID 10395213.
  2. ^ Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE (July 2005). "Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test". Neuropsychopharmacology. 30 (7): 1257–68. doi:10.1038/sj.npp.1300677. PMID 15688083.