CYP2W1 Knowpia

CYP2W1
Identifiers
Aliases	CYP2W1, cytochrome P450 family 2 subfamily W member 1
External IDs	OMIM: 615967 MGI: 3616076 HomoloGene: 69239 GeneCards: CYP2W1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	989,640 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,342,788 bp
RNA expression pattern
	Top expressed in
	vena cava; ; skin of abdomen; ; internal globus pallidus; ; sural nerve; ; spongy bone; ; amniotic fluid; ; pancreatic ductal cell; ; duodenum; ; body of tongue; ; nipple;
	Top expressed in
	lip; ; zone of skin; ; esophagus; ; ileum; ; colon; ; stomach; ; jejunum; ; limb; ; duodenum; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;
Cellular component	cell surface; plasma membrane; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; cytoplasm; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; epoxygenase P450 pathway; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54905
	545817
	ENSG00000073067
	ENSMUSG00000029541
	Q8TAV3
	E9Q816
	NM_017781
	NM_001160265
	NP_060251
	NP_001153737
	Wikidata
View/Edit Human	View/Edit Mouse

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.^[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073067 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029541 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
^ This article incorporates public domain material from "Entrez Gene: CYP2W1". Reference Sequence collection. National Center for Biotechnology Information.

External links edit

Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.

Further reading edit

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073067 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029541 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15489334-5] Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[entrez_2532-6] This article incorporates public domain material from "Entrez Gene: CYP2W1". Reference Sequence collection. National Center for Biotechnology Information.

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Summary

References edit

External links edit

Further reading edit