BREAKING NEWS
Cloud Server Hosting For Online Businesses
Inexpensive SEO Services
Benefits of Wanting to play Free Online Slot machines
CYP6 family

Summary

Cytochrome P450, family 6, also known as CYP6, is a cytochrome P450 family found in Insect genome. CYP6 and CYP9, another insect CYP family, belong to the same clan as mammalian CYP3 and CYP5 families.[1]

The first two CYP6 subfamilies represented by CYP6A1 and CYP6B1 shared only 32.7% identity,[2] less than the typical CYP subfamilies, which share at least 40% amino acid identity.[3]

Many of the enzymes in this family like CYP6G1 (DDT-R) in Drosophila melanogaster[4] and CYP6B in Helicoverpa armigera[5] are related to insecticide resistance.

References edit

  1. ^ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
  2. ^ Dermauw, W; Van Leeuwen, T; Feyereisen, R (December 2020). "Diversity and evolution of the P450 family in arthropods". Insect Biochemistry and Molecular Biology. 127: 103490. doi:10.1016/j.ibmb.2020.103490. hdl:1854/LU-8689608. PMID 33169702. S2CID 226297890.
  3. ^ Nelson, DR (2006). "Cytochrome P450 Nomenclature, 2004". Cytochrome P450 Protocols. Methods in Molecular Biology. Vol. 320. pp. 1–10. doi:10.1385/1-59259-998-2:1. ISBN 1-59259-998-2. PMID 16719369.
  4. ^ Le Goff, G; Hilliou, F (March 2017). "Resistance evolution in Drosophila: the case of CYP6G1". Pest Management Science. 73 (3): 493–499. doi:10.1002/ps.4470. PMID 27787942.
  5. ^ Shi, Y; Jiang, Q; Yang, Y; Feyereisen, R; Wu, Y (August 2021). "Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies". Insect Biochemistry and Molecular Biology. 135: 103597. doi:10.1016/j.ibmb.2021.103597. PMID 34089822. S2CID 235353940.