In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source.[1] The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions.[2]
Cache domain | |||||||||
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Identifiers | |||||||||
Symbol | Cache_1 | ||||||||
Pfam | PF02743 | ||||||||
Pfam clan | CL0165 | ||||||||
InterPro | IPR004010 | ||||||||
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Cache domain (type 2) | |||||||||
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Identifiers | |||||||||
Symbol | Cache_2 | ||||||||
Pfam | PF08269 | ||||||||
Pfam clan | CL0165 | ||||||||
InterPro | IPR013163 | ||||||||
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