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**Calculus** is the mathematical study of continuous change, in the same way that geometry is the study of shape, and algebra is the study of generalizations of arithmetic operations.

Originally called **infinitesimal calculus** or "the calculus of infinitesimals", it has two major branches, differential calculus and integral calculus. The former concerns instantaneous rates of change, and the slopes of curves, while the latter concerns accumulation of quantities, and areas under or between curves. These two branches are related to each other by the fundamental theorem of calculus. They make use of the fundamental notions of convergence of infinite sequences and infinite series to a well-defined limit.^{[1]}

Infinitesimal calculus was developed independently in the late 17th century by Isaac Newton and Gottfried Wilhelm Leibniz.^{[2]}^{[3]} Later work, including codifying the idea of limits, put these developments on a more solid conceptual footing. Today, calculus has widespread uses in science, engineering, and social science.^{[4]}

Look up **calculus** in Wiktionary, the free dictionary.

In mathematics education, *calculus* is an abbreviation of both infinitesimal calculus and integral calculus, which denotes courses of elementary mathematical analysis.

In Latin, the word *calculus* means “small pebble”, (the diminutive of *calx,* meaning "stone"), a meaning which still persists in medicine. Because such pebbles were used for counting out distances,^{[5]} tallying votes, and doing abacus arithmetic, the word came to be the Latin word for *calculation*. In this sense, it was used in English at least as early as 1672, several years before the publications of Leibniz and Newton, who wrote their mathematical texts in Latin.^{[6]}

In addition to differential calculus and integral calculus, the term is also used for naming specific methods of computation or theories that imply some sort of computation. Examples of this usage include propositional calculus, Ricci calculus, calculus of variations, lambda calculus, sequent calculus, and process calculus. Furthermore, the term "calculus" has variously been applied in ethics and philosophy, for such systems as Bentham's felicific calculus, and the ethical calculus.

Modern calculus was developed in 17th-century Europe by Isaac Newton and Gottfried Wilhelm Leibniz (independently of each other, first publishing around the same time) but elements of it first appeared in ancient Egypt and later Greece, then in China and the Middle East, and still later again in medieval Europe and India.

Calculations of volume and area, one goal of integral calculus, can be found in the Egyptian Moscow papyrus (c. 1820 BC), but the formulae are simple instructions, with no indication as to how they were obtained.^{[7]}^{[8]}

Laying the foundations for integral calculus and foreshadowing the concept of the limit, ancient Greek mathematician Eudoxus of Cnidus (c. 390 – 337 BC) developed the method of exhaustion to prove the formulas for cone and pyramid volumes.

During the Hellenistic period, this method was further developed by Archimedes (c. 287 – c. 212 BC), who combined it with a concept of the indivisibles—a precursor to infinitesimals—allowing him to solve several problems now treated by integral calculus. In *The Method of Mechanical Theorems* he describes, for example, calculating the center of gravity of a solid hemisphere, the center of gravity of a frustum of a circular paraboloid, and the area of a region bounded by a parabola and one of its secant lines.^{[9]}

The method of exhaustion was later discovered independently in China by Liu Hui in the 3rd century AD to find the area of a circle.^{[10]}^{[11]} In the 5th century AD, Zu Gengzhi, son of Zu Chongzhi, established a method^{[12]}^{[13]} that would later be called Cavalieri's principle to find the volume of a sphere.

In the Middle East, Hasan Ibn al-Haytham, Latinized as Alhazen (c. 965 – c. 1040 AD) derived a formula for the sum of fourth powers. He used the results to carry out what would now be called an integration of this function, where the formulae for the sums of integral squares and fourth powers allowed him to calculate the volume of a paraboloid.^{[14]}

Bhāskara II (c.1114–1185) was acquainted with some ideas of differential calculus and suggested that the "differential coefficient" vanishes at an extremum value of the function.^{[15]} In his astronomical work, he gave a procedure that looked like a precursor to infinitesimal methods. Namely, if then This can be interpreted as the discovery that cosine is the derivative of sine.^{[16]}
In the 14th century, Indian mathematicians gave a non-rigorous method, resembling differentiation, applicable to some trigonometric functions. Madhava of Sangamagrama and the Kerala School of Astronomy and Mathematics stated components of calculus, but according to Victor J. Katz they were not able to "combine many differing ideas under the two unifying themes of the derivative and the integral, show the connection between the two, and turn calculus into the great problem-solving tool we have today".^{[14]}

Johannes Kepler's work *Stereometria Doliorum* (1615) formed the basis of integral calculus.^{[17]} Kepler developed a method to calculate the area of an ellipse by adding up the lengths of many radii drawn from a focus of the ellipse.^{[18]}

Significant work was a treatise, the origin being Kepler's methods,^{[18]} written by Bonaventura Cavalieri, who argued that volumes and areas should be computed as the sums of the volumes and areas of infinitesimally thin cross-sections. The ideas were similar to Archimedes' in *The Method*, but this treatise is believed to have been lost in the 13th century and was only rediscovered in the early 20th century, and so would have been unknown to Cavalieri. Cavalieri's work was not well respected since his methods could lead to erroneous results, and the infinitesimal quantities he introduced were disreputable at first.

The formal study of calculus brought together Cavalieri's infinitesimals with the calculus of finite differences developed in Europe at around the same time. Pierre de Fermat, claiming that he borrowed from Diophantus, introduced the concept of adequality, which represented equality up to an infinitesimal error term.^{[19]} The combination was achieved by John Wallis, Isaac Barrow, and James Gregory, the latter two proving predecessors to the second fundamental theorem of calculus around 1670.^{[20]}^{[21]}

The product rule and chain rule,^{[22]} the notions of higher derivatives and Taylor series,^{[23]} and of analytic functions^{[24]} were used by Isaac Newton in an idiosyncratic notation which he applied to solve problems of mathematical physics. In his works, Newton rephrased his ideas to suit the mathematical idiom of the time, replacing calculations with infinitesimals by equivalent geometrical arguments which were considered beyond reproach. He used the methods of calculus to solve the problem of planetary motion, the shape of the surface of a rotating fluid, the oblateness of the earth, the motion of a weight sliding on a cycloid, and many other problems discussed in his *Principia Mathematica* (1687). In other work, he developed series expansions for functions, including fractional and irrational powers, and it was clear that he understood the principles of the Taylor series. He did not publish all these discoveries, and at this time infinitesimal methods were still considered disreputable.^{[25]}

These ideas were arranged into a true calculus of infinitesimals by Gottfried Wilhelm Leibniz, who was originally accused of plagiarism by Newton.^{[26]} He is now regarded as an independent inventor of and contributor to calculus. His contribution was to provide a clear set of rules for working with infinitesimal quantities, allowing the computation of second and higher derivatives, and providing the product rule and chain rule, in their differential and integral forms. Unlike Newton, Leibniz put painstaking effort into his choices of notation.^{[27]}

Today, Leibniz and Newton are usually both given credit for independently inventing and developing calculus. Newton was the first to apply calculus to general physics. Leibniz developed much of the notation used in calculus today.^{[28]}^{: 51–52 } The basic insights that both Newton and Leibniz provided were the laws of differentiation and integration, emphasizing that differentiation and integration are inverse processes, second and higher derivatives, and the notion of an approximating polynomial series.

When Newton and Leibniz first published their results, there was great controversy over which mathematician (and therefore which country) deserved credit. Newton derived his results first (later to be published in his *Method of Fluxions*), but Leibniz published his "Nova Methodus pro Maximis et Minimis" first. Newton claimed Leibniz stole ideas from his unpublished notes, which Newton had shared with a few members of the Royal Society. This controversy divided English-speaking mathematicians from continental European mathematicians for many years, to the detriment of English mathematics.^{[29]} A careful examination of the papers of Leibniz and Newton shows that they arrived at their results independently, with Leibniz starting first with integration and Newton with differentiation. It is Leibniz, however, who gave the new discipline its name. Newton called his calculus "the science of fluxions", a term that endured in English schools into the 19th century.^{[30]}^{: 100 } The first complete treatise on calculus to be written in English and use the Leibniz notation was not published until 1815.^{[31]}

Since the time of Leibniz and Newton, many mathematicians have contributed to the continuing development of calculus. One of the first and most complete works on both infinitesimal and integral calculus was written in 1748 by Maria Gaetana Agnesi.^{[32]}^{[33]}

In calculus, *foundations* refers to the rigorous development of the subject from axioms and definitions. In early calculus, the use of infinitesimal quantities was thought unrigorous and was fiercely criticized by several authors, most notably Michel Rolle and Bishop Berkeley. Berkeley famously described infinitesimals as the ghosts of departed quantities in his book *The Analyst* in 1734. Working out a rigorous foundation for calculus occupied mathematicians for much of the century following Newton and Leibniz, and is still to some extent an active area of research today.^{[34]}

Several mathematicians, including Maclaurin, tried to prove the soundness of using infinitesimals, but it would not be until 150 years later when, due to the work of Cauchy and Weierstrass, a way was finally found to avoid mere "notions" of infinitely small quantities.^{[35]} The foundations of differential and integral calculus had been laid. In Cauchy's *Cours d'Analyse*, we find a broad range of foundational approaches, including a definition of continuity in terms of infinitesimals, and a (somewhat imprecise) prototype of an (ε, δ)-definition of limit in the definition of differentiation.^{[36]} In his work Weierstrass formalized the concept of limit and eliminated infinitesimals (although his definition can validate nilsquare infinitesimals). Following the work of Weierstrass, it eventually became common to base calculus on limits instead of infinitesimal quantities, though the subject is still occasionally called "infinitesimal calculus". Bernhard Riemann used these ideas to give a precise definition of the integral.^{[37]} It was also during this period that the ideas of calculus were generalized to the complex plane with the development of complex analysis.^{[38]}

In modern mathematics, the foundations of calculus are included in the field of real analysis, which contains full definitions and proofs of the theorems of calculus. The reach of calculus has also been greatly extended. Henri Lebesgue invented measure theory, based on earlier developments by Émile Borel, and used it to define integrals of all but the most pathological functions.^{[39]} Laurent Schwartz introduced distributions, which can be used to take the derivative of any function whatsoever.^{[40]}

Limits are not the only rigorous approach to the foundation of calculus. Another way is to use Abraham Robinson's non-standard analysis. Robinson's approach, developed in the 1960s, uses technical machinery from mathematical logic to augment the real number system with infinitesimal and infinite numbers, as in the original Newton-Leibniz conception. The resulting numbers are called hyperreal numbers, and they can be used to give a Leibniz-like development of the usual rules of calculus.^{[41]} There is also smooth infinitesimal analysis, which differs from non-standard analysis in that it mandates neglecting higher-power infinitesimals during derivations.^{[34]} Based on the ideas of F. W. Lawvere and employing the methods of category theory, smooth infinitesimal analysis views all functions as being continuous and incapable of being expressed in terms of discrete entities. One aspect of this formulation is that the law of excluded middle does not hold.^{[34]} The law of excluded middle is also rejected in constructive mathematics, a branch of mathematics that insists that proofs of the existence of a number, function, or other mathematical object should give a construction of the object. Reformulations of calculus in a constructive framework are generally part of the subject of constructive analysis.^{[34]}

While many of the ideas of calculus had been developed earlier in Greece, China, India, Iraq, Persia, and Japan, the use of calculus began in Europe, during the 17th century, when Newton and Leibniz built on the work of earlier mathematicians to introduce its basic principles.^{[11]}^{[25]}^{[42]} The Hungarian polymath John von Neumann wrote of this work,

The calculus was the first achievement of modern mathematics and it is difficult to overestimate its importance. I think it defines more unequivocally than anything else the inception of modern mathematics, and the system of mathematical analysis, which is its logical development, still constitutes the greatest technical advance in exact thinking.

^{[43]}

Applications of differential calculus include computations involving velocity and acceleration, the slope of a curve, and optimization.^{[44]}^{: 341–453 } Applications of integral calculus include computations involving area, volume, arc length, center of mass, work, and pressure.^{[44]}^{: 685–700 } More advanced applications include power series and Fourier series.

Calculus is also used to gain a more precise understanding of the nature of space, time, and motion. For centuries, mathematicians and philosophers wrestled with paradoxes involving division by zero or sums of infinitely many numbers. These questions arise in the study of motion and area. The ancient Greek philosopher Zeno of Elea gave several famous examples of such paradoxes. Calculus provides tools, especially the limit and the infinite series, that resolve the paradoxes.^{[45]}

Calculus is usually developed by working with very small quantities. Historically, the first method of doing so was by infinitesimals. These are objects which can be treated like real numbers but which are, in some sense, "infinitely small". For example, an infinitesimal number could be greater than 0, but less than any number in the sequence 1, 1/2, 1/3, ... and thus less than any positive real number. From this point of view, calculus is a collection of techniques for manipulating infinitesimals. The symbols and were taken to be infinitesimal, and the derivative was their ratio.^{[34]}

The infinitesimal approach fell out of favor in the 19th century because it was difficult to make the notion of an infinitesimal precise. In the late 19th century, infinitesimals were replaced within academia by the epsilon, delta approach to limits. Limits describe the behavior of a function at a certain input in terms of its values at nearby inputs. They capture small-scale behavior using the intrinsic structure of the real number system (as a metric space with the least-upper-bound property). In this treatment, calculus is a collection of techniques for manipulating certain limits. Infinitesimals get replaced by sequences of smaller and smaller numbers, and the infinitely small behavior of a function is found by taking the limiting behavior for these sequences. Limits were thought to provide a more rigorous foundation for calculus, and for this reason, they became the standard approach during the 20th century. However, the infinitesimal concept was revived in the 20th century with the introduction of non-standard analysis and smooth infinitesimal analysis, which provided solid foundations for the manipulation of infinitesimals.^{[34]}

Differential calculus is the study of the definition, properties, and applications of the derivative of a function. The process of finding the derivative is called *differentiation*. Given a function and a point in the domain, the derivative at that point is a way of encoding the small-scale behavior of the function near that point. By finding the derivative of a function at every point in its domain, it is possible to produce a new function, called the *derivative function* or just the *derivative* of the original function. In formal terms, the derivative is a linear operator which takes a function as its input and produces a second function as its output. This is more abstract than many of the processes studied in elementary algebra, where functions usually input a number and output another number. For example, if the doubling function is given the input three, then it outputs six, and if the squaring function is given the input three, then it outputs nine. The derivative, however, can take the squaring function as an input. This means that the derivative takes all the information of the squaring function—such as that two is sent to four, three is sent to nine, four is sent to sixteen, and so on—and uses this information to produce another function. The function produced by differentiating the squaring function turns out to be the doubling function.^{[28]}^{: 32 }

In more explicit terms the "doubling function" may be denoted by *g*(*x*) = 2*x* and the "squaring function" by *f*(*x*) = *x*^{2}. The "derivative" now takes the function *f*(*x*), defined by the expression "*x*^{2}", as an input, that is all the information—such as that two is sent to four, three is sent to nine, four is sent to sixteen, and so on—and uses this information to output another function, the function *g*(*x*) = 2*x*, as will turn out.

In Lagrange's notation, the symbol for a derivative is an apostrophe-like mark called a prime. Thus, the derivative of a function called *f* is denoted by *f′*, pronounced "f prime" or "f dash". For instance, if *f*(*x*) = *x*^{2} is the squaring function, then *f′*(*x*) = 2*x* is its derivative (the doubling function *g* from above).

If the input of the function represents time, then the derivative represents change concerning time. For example, if *f* is a function that takes time as input and gives the position of a ball at that time as output, then the derivative of *f* is how the position is changing in time, that is, it is the velocity of the ball.^{[28]}^{: 18–20 }

If a function is linear (that is if the graph of the function is a straight line), then the function can be written as *y* = *mx* + *b*, where *x* is the independent variable, *y* is the dependent variable, *b* is the *y*-intercept, and:

This gives an exact value for the slope of a straight line.^{[46]}^{: 6 } If the graph of the function is not a straight line, however, then the change in *y* divided by the change in *x* varies. Derivatives give an exact meaning to the notion of change in output concerning change in input. To be concrete, let *f* be a function, and fix a point *a* in the domain of *f*. (*a*, *f*(*a*)) is a point on the graph of the function. If *h* is a number close to zero, then *a* + *h* is a number close to *a*. Therefore, (*a* + *h*, *f*(*a* + *h*)) is close to (*a*, *f*(*a*)). The slope between these two points is

This expression is called a *difference quotient*. A line through two points on a curve is called a *secant line*, so *m* is the slope of the secant line between (*a*, *f*(*a*)) and (*a* + *h*, *f*(*a* + *h*)). The second line is only an approximation to the behavior of the function at the point * a* because it does not account for what happens between * a* and * a* + *h*. It is not possible to discover the behavior at * a* by setting *h* to zero because this would require dividing by zero, which is undefined. The derivative is defined by taking the limit as *h* tends to zero, meaning that it considers the behavior of *f* for all small values of *h* and extracts a consistent value for the case when *h* equals zero:

Geometrically, the derivative is the slope of the tangent line to the graph of *f* at * a*. The tangent line is a limit of secant lines just as the derivative is a limit of difference quotients. For this reason, the derivative is sometimes called the slope of the function *f*.^{[46]}^{: 61–63 }

Here is a particular example, the derivative of the squaring function at the input 3. Let *f*(*x*) = *x*^{2} be the squaring function.

The slope of the tangent line to the squaring function at the point (3, 9) is 6, that is to say, it is going up six times as fast as it is going to the right. The limit process just described can be performed for any point in the domain of the squaring function. This defines the *derivative function* of the squaring function or just the *derivative* of the squaring function for short. A computation similar to the one above shows that the derivative of the squaring function is the doubling function.^{[46]}^{: 63 }

A common notation, introduced by Leibniz, for the derivative in the example above is

In an approach based on limits, the symbol *dy*/* dx* is to be interpreted not as the quotient of two numbers but as a shorthand for the limit computed above.^{[46]}^{: 74 } Leibniz, however, did intend it to represent the quotient of two infinitesimally small numbers, *dy* being the infinitesimally small change in *y* caused by an infinitesimally small change * dx* applied to *x*. We can also think of *d*/* dx* as a differentiation operator, which takes a function as an input and gives another function, the derivative, as the output. For example:

In this usage, the *dx* in the denominator is read as "with respect to *x*".^{[46]}^{: 79 } Another example of correct notation could be:

Even when calculus is developed using limits rather than infinitesimals, it is common to manipulate symbols like * dx* and *dy* as if they were real numbers; although it is possible to avoid such manipulations, they are sometimes notationally convenient in expressing operations such as the total derivative.

*Integral calculus* is the study of the definitions, properties, and applications of two related concepts, the *indefinite integral* and the *definite integral*. The process of finding the value of an integral is called *integration*.^{[44]}^{: 508 } The indefinite integral, also known as the *antiderivative*, is the inverse operation to the derivative.^{[46]}^{: 163–165 } *F* is an indefinite integral of *f* when *f* is a derivative of *F*. (This use of lower- and upper-case letters for a function and its indefinite integral is common in calculus.) The definite integral inputs a function and outputs a number, which gives the algebraic sum of areas between the graph of the input and the x-axis. The technical definition of the definite integral involves the limit of a sum of areas of rectangles, called a Riemann sum.^{[47]}^{: 282 }

A motivating example is the distance traveled in a given time.^{[46]}^{: 153 } If the speed is constant, only multiplication is needed:

But if the speed changes, a more powerful method of finding the distance is necessary. One such method is to approximate the distance traveled by breaking up the time into many short intervals of time, then multiplying the time elapsed in each interval by one of the speeds in that interval, and then taking the sum (a Riemann sum) of the approximate distance traveled in each interval. The basic idea is that if only a short time elapses, then the speed will stay more or less the same. However, a Riemann sum only gives an approximation of the distance traveled. We must take the limit of all such Riemann sums to find the exact distance traveled.

When velocity is constant, the total distance traveled over the given time interval can be computed by multiplying velocity and time. For example, traveling a steady 50 mph for 3 hours results in a total distance of 150 miles. Plotting the velocity as a function of time yields a rectangle with a height equal to the velocity and a width equal to the time elapsed. Therefore, the product of velocity and time also calculates the rectangular area under the (constant) velocity curve.^{[44]}^{: 535 } This connection between the area under a curve and the distance traveled can be extended to *any* irregularly shaped region exhibiting a fluctuating velocity over a given period. If *f*(*x*) represents speed as it varies over time, the distance traveled between the times represented by * a* and *b* is the area of the region between *f*(*x*) and the *x*-axis, between *x* = *a* and *x* = *b*.

To approximate that area, an intuitive method would be to divide up the distance between * a* and *b* into several equal segments, the length of each segment represented by the symbol Δ*x*. For each small segment, we can choose one value of the function *f*(*x*). Call that value *h*. Then the area of the rectangle with base Δ*x* and height *h* gives the distance (time Δ*x* multiplied by speed *h*) traveled in that segment. Associated with each segment is the average value of the function above it, *f*(*x*) = *h*. The sum of all such rectangles gives an approximation of the area between the axis and the curve, which is an approximation of the total distance traveled. A smaller value for Δ*x* will give more rectangles and in most cases a better approximation, but for an exact answer, we need to take a limit as Δ*x* approaches zero.^{[44]}^{: 512–522 }

The symbol of integration is , an elongated *S* chosen to suggest summation.^{[44]}^{: 529 } The definite integral is written as:

and is read "the integral from *a* to *b* of *f*-of-*x* with respect to *x*." The Leibniz notation * dx* is intended to suggest dividing the area under the curve into an infinite number of rectangles so that their width Δ*x* becomes the infinitesimally small * dx*.^{[28]}^{: 44 }

The indefinite integral, or antiderivative, is written:

Functions differing by only a constant have the same derivative, and it can be shown that the antiderivative of a given function is a family of functions differing only by a constant.^{[47]}^{: 326 } Since the derivative of the function *y* = *x*^{2} + *C*, where *C* is any constant, is *y′* = 2*x*, the antiderivative of the latter is given by:

The unspecified constant * C* present in the indefinite integral or antiderivative is known as the constant of integration.^{[48]}^{: 135 }

The fundamental theorem of calculus states that differentiation and integration are inverse operations.^{[47]}^{: 290 } More precisely, it relates the values of antiderivatives to definite integrals. Because it is usually easier to compute an antiderivative than to apply the definition of a definite integral, the fundamental theorem of calculus provides a practical way of computing definite integrals. It can also be interpreted as a precise statement of the fact that differentiation is the inverse of integration.

The fundamental theorem of calculus states: If a function *f* is continuous on the interval [*a*, *b*] and if *F* is a function whose derivative is *f* on the interval (*a*, *b*), then

Furthermore, for every *x* in the interval (*a*, *b*),

This realization, made by both Newton and Leibniz, was key to the proliferation of analytic results after their work became known. (The extent to which Newton and Leibniz were influenced by immediate predecessors, and particularly what Leibniz may have learned from the work of Isaac Barrow, is difficult to determine because of the priority dispute between them.^{[49]}) The fundamental theorem provides an algebraic method of computing many definite integrals—without performing limit processes—by finding formulae for antiderivatives. It is also a prototype solution of a differential equation. Differential equations relate an unknown function to its derivatives and are ubiquitous in the sciences.^{[50]}^{: 351–352 }

Calculus is used in every branch of the physical sciences,^{[51]}^{: 1 } actuarial science, computer science, statistics, engineering, economics, business, medicine, demography, and in other fields wherever a problem can be mathematically modeled and an optimal solution is desired.^{[52]} It allows one to go from (non-constant) rates of change to the total change or vice versa, and many times in studying a problem we know one and are trying to find the other.^{[53]} Calculus can be used in conjunction with other mathematical disciplines. For example, it can be used with linear algebra to find the "best fit" linear approximation for a set of points in a domain. Or, it can be used in probability theory to determine the expectation value of a continuous random variable given a probability density function.^{[54]}^{: 37 } In analytic geometry, the study of graphs of functions, calculus is used to find high points and low points (maxima and minima), slope, concavity and inflection points. Calculus is also used to find approximate solutions to equations; in practice, it is the standard way to solve differential equations and do root finding in most applications. Examples are methods such as Newton's method, fixed point iteration, and linear approximation. For instance, spacecraft use a variation of the Euler method to approximate curved courses within zero gravity environments.

Physics makes particular use of calculus; all concepts in classical mechanics and electromagnetism are related through calculus. The mass of an object of known density, the moment of inertia of objects, and the potential energies due to gravitational and electromagnetic forces can all be found by the use of calculus. An example of the use of calculus in mechanics is Newton's second law of motion, which states that the derivative of an object's momentum concerning time equals the net force upon it. Alternatively, Newton's second law can be expressed by saying that the net force equals the object's mass times its acceleration, which is the time derivative of velocity and thus the second time derivative of spatial position. Starting from knowing how an object is accelerating, we use calculus to derive its path.^{[55]}

Maxwell's theory of electromagnetism and Einstein's theory of general relativity are also expressed in the language of differential calculus.^{[56]}^{[57]}^{: 52–55 } Chemistry also uses calculus in determining reaction rates^{[58]}^{: 599 } and in studying radioactive decay.^{[58]}^{: 814 } In biology, population dynamics starts with reproduction and death rates to model population changes.^{[59]}^{[60]}^{: 631 }

Green's theorem, which gives the relationship between a line integral around a simple closed curve C and a double integral over the plane region D bounded by C, is applied in an instrument known as a planimeter, which is used to calculate the area of a flat surface on a drawing.^{[61]} For example, it can be used to calculate the amount of area taken up by an irregularly shaped flower bed or swimming pool when designing the layout of a piece of property.

In the realm of medicine, calculus can be used to find the optimal branching angle of a blood vessel to maximize flow.^{[62]} Calculus can be applied to understand how quickly a drug is eliminated from a body or how quickly a cancerous tumor grows.^{[63]}

In economics, calculus allows for the determination of maximal profit by providing a way to easily calculate both marginal cost and marginal revenue.^{[64]}^{: 387 }

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^{a}^{b}Chisholm, Hugh, ed. (1911). .*Encyclopædia Britannica*. Vol. 14 (11th ed.). Cambridge University Press. p. 537. **^**Weil, André (1984).*Number theory: An approach through History from Hammurapi to Legendre*. Boston: Birkhauser Boston. p. 28. ISBN 0-8176-4565-9.**^**Hollingdale, Stuart (1991). "Review of Before Newton: The Life and Times of Isaac Barrow".*Notes and Records of the Royal Society of London*.**45**(2): 277–279. doi:10.1098/rsnr.1991.0027. ISSN 0035-9149. JSTOR 531707. S2CID 165043307.The most interesting to us are Lectures X–XII, in which Barrow comes close to providing a geometrical demonstration of the fundamental theorem of the calculus... He did not realize, however, the full significance of his results, and his rejection of algebra means that his work must remain a piece of mid-17th century geometrical analysis of mainly historic interest.

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^{a}^{b}^{c}^{d}^{e}^{f}Bell, John L. (6 September 2013). "Continuity and Infinitesimals".*Stanford Encyclopedia of Philosophy*. Archived from the original on 16 March 2022. Retrieved 20 February 2022. **^**Russell, Bertrand (1946).*History of Western Philosophy*. London: George Allen & Unwin Ltd. p. 857.The great mathematicians of the seventeenth century were optimistic and anxious for quick results; consequently they left the foundations of analytical geometry and the infinitesimal calculus insecure. Leibniz believed in actual infinitesimals, but although this belief suited his metaphysics it had no sound basis in mathematics. Weierstrass, soon after the middle of the nineteenth century, showed how to establish calculus without infinitesimals, and thus, at last, made it logically secure. Next came Georg Cantor, who developed the theory of continuity and infinite number. "Continuity" had been, until he defined it, a vague word, convenient for philosophers like Hegel, who wished to introduce metaphysical muddles into mathematics. Cantor gave a precise significance to the word and showed that continuity, as he defined it, was the concept needed by mathematicians and physicists. By this means a great deal of mysticism, such as that of Bergson, was rendered antiquated.

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^{a}^{b}^{c}^{d}^{e}^{f}Herman, Edwin; Strang, Gilbert; et al. (2017).*Calculus*. Vol. 1. Houston, Texas: OpenStax. ISBN 978-1-938168-02-4. OCLC 1022848630. Archived from the original on 23 September 2022. Retrieved 26 July 2022. **^**Cheng, Eugenia (2017).*Beyond Infinity: An Expedition to the Outer Limits of Mathematics*. Basic Books. pp. 206–210. ISBN 978-1-541-64413-7. OCLC 1003309980.- ^
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^{a}^{b}^{c}Hughes-Hallett, Deborah; McCallum, William G.; Gleason, Andrew M.; et al. (2013).*Calculus: Single and Multivariable*(6th ed.). Hoboken, NJ: Wiley. ISBN 978-0-470-88861-2. OCLC 794034942. **^**Moebs, William; Ling, Samuel J.; Sanny, Jeff; et al. (2022).*University Physics, Volume 1*. OpenStax. ISBN 978-1-947172-20-3. OCLC 961352944.**^**See, for example:- Mahoney, Michael S. (1990). "Barrow's mathematics: Between ancients and moderns". In Feingold, M. (ed.).
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*Isis*.**84**(2): 310–338. Bibcode:1993Isis...84..310F. doi:10.1086/356464. ISSN 0021-1753. S2CID 144019197. - Probst, Siegmund (2015). "Leibniz as Reader and Second Inventor: The Cases of Barrow and Mengoli". In Goethe, Norma B.; Beeley, Philip; Rabouin, David (eds.).
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