According to the Trewartha climate classification system, Cape Lookout, North Carolina has a humid subtropical climate with hot and humid summers, cool winters and year-around precipitation (Cfak). Cfak climates are characterized by all months having an average mean temperature > 32.0 °F (> 0.0 °C), at least eight months with an average mean temperature ≥ 50.0 °F (≥ 10.0 °C), at least one month with an average mean temperature ≥ 71.6 °F (≥ 22.0 °C) and no significant precipitation difference between seasons. During the summer months in Cape Lookout, a cooling afternoon sea breeze is present on most days, but episodes of extreme heat and humidity can occur with heat index values ≥ 100 °F (≥ 38 °C). Cape Lookout is prone to hurricane strikes, particularly during the Atlantic hurricane season which extends from June 1 through November 30, sharply peaking from late August through September. During the winter months, episodes of cold and wind can occur with wind chill values < 10 °F (< -12 °C). The plant hardiness zone in Cape Lookout is 8b with an average annual extreme minimum air temperature of 14.6 °F (-9.7 °C).^[4] The average seasonal (Dec-Mar) snowfall total is < 2 inches (< 5 cm), and the average annual peak in nor'easter activity is in February.

According to the A. W. Kuchler U.S. potential natural vegetation types, Cape Lookout, North Carolina would have a dominant vegetation type of Live oak/Sea Oats Uniola paniculata (90) with a dominant vegetation form of Coastal Prairie (20).^[7]

34°36′19″N 76°32′10″W / 34.60528°N 76.53611°W / 34.60528; -76.53611