3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||76.13 g·mol−1|
|Density||1.539 g/cm3 (−186°C)|
1.2927 g/cm3 (0 °C)
1.266 g/cm3 (25 °C)
|Melting point||−111.61 °C (−168.90 °F; 161.54 K)|
|Boiling point||46.24 °C (115.23 °F; 319.39 K)|
|2.58 g/L (0 °C)|
2.39 g/L (10 °C)
2.17 g/L (20 °C)
0.14 g/L (50 °C)
|Solubility||Soluble in alcohol, ether, benzene, oil, CHCl3, CCl4|
|Solubility in formic acid||4.66 g/100 g|
|Solubility in dimethyl sulfoxide||45 g/100 g (20.3 °C)|
|Vapor pressure||48.1 kPa (25 °C)|
82.4 kPa (40 °C)
Refractive index (nD)
|Viscosity||0.436 cP (0 °C)|
0.363 cP (20 °C)
|0 D (20 °C)|
Heat capacity (C)
Std enthalpy of
Gibbs free energy (ΔfG˚)
Std enthalpy of
|Safety data sheet||See: data page|
|GHS Signal word||Danger|
|H225, H315, H319, H361, H372|
|P210, P281, P305+P351+P338, P314|
|Inhalation hazard||Irritant; toxic|
|NFPA 704 (fire diamond)|
|Flash point||−43 °C (−45 °F; 230 K)|
|102 °C (216 °F; 375 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|3188 mg/kg (rat, oral)|
LC50 (median concentration)
|>1670 ppm (rat, 1 h)|
15500 ppm (rat, 1 h)
3000 ppm (rat, 4 h)
3500 ppm (rat, 4 h)
7911 ppm (rat, 2 h)
3165 ppm (mouse, 2 h)
LCLo (lowest published)
|4000 ppm (human, 30 min)|
|NIOSH (US health exposure limits):|
|TWA 20 ppm C 30 ppm 100 ppm (30-minute maximum peak)|
|TWA 1 ppm (3 mg/m3) ST 10 ppm (30 mg/m3) [skin]|
IDLH (Immediate danger)
|Supplementary data page|
|Refractive index (n),|
Dielectric constant (εr), etc.
|UV, IR, NMR, MS|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|(what is ?)|
Carbon disulfide, also spelled as carbon disulphide, is a neurotoxic colorless volatile liquid with the formula CS2. The compound is used frequently as a building block in organic chemistry as well as an industrial and chemical non-polar solvent. It has an "ether-like" odor, but commercial samples are typically contaminated with foul-smelling impurities.
The reaction is analogous to the combustion of methane.
Global production/consumption of carbon disulfide is approximately one million tonnes, with China consuming 49%, followed by India at 13%, mostly for the production of rayon fiber. United States production in 2007 was 56,000 tonnes.
CS2 is highly flammable. Its combustion affords sulfur dioxide according to this ideal stoichiometry:
Compared to the isoelectronic carbon dioxide, CS2 is a weaker electrophile. While, however, reactions of nucleophiles with CO2 are highly reversible and products are only isolated with very strong nucleophiles, the reactions with CS2 are thermodynamically more favored allowing the formation of products with less reactive nucleophiles. For example, amines afford dithiocarbamates:
This reaction is the basis of the manufacture of regenerated cellulose, the main ingredient of viscose, rayon and cellophane. Both xanthates and the related thioxanthates (derived from treatment of CS2 with sodium thiolates) are used as flotation agents in mineral processing.
Sodium sulfide affords trithiocarbonate:
Carbon disulfide does not hydrolyze readily, although the process is catalyzed by an enzyme carbon disulfide hydrolase.
This conversion proceeds via the intermediacy of thiophosgene, CSCl2.
CS2 polymerizes upon photolysis or under high pressure to give an insoluble material called car-sul or "Bridgman's black", named after the discoverer of the polymer, Percy Williams Bridgman. Trithiocarbonate (-S-C(S)-S-) linkages comprise, in part, the backbone of the polymer, which is a semiconductor.
It is also a valued intermediate in chemical synthesis of carbon tetrachloride. It is widely used in the synthesis of organosulfur compounds such as metam sodium, xanthates and dithiocarbamates, which are used in extractive metallurgy and rubber chemistry.
It can be used in fumigation of airtight storage warehouses, airtight flat storages, bins, grain elevators, railroad box cars, shipholds, barges and cereal mills. Carbon disulfide is also used as an insecticide for the fumigation of grains, nursery stock, in fresh fruit conservation and as a soil disinfectant against insects and nematodes.
Carbon disulfide has been linked to both acute and chronic forms of poisoning, with a diverse range of symptoms.
Concentrations of 500-3000 mg/m3 cause acute and subacute poisoning cause a set of mostly neurological and psychiatric symptoms, called encephalopathia sulfocarbonica. Symptoms include acute psychosis (manic delirium, hallucinations), paranoic ideas, loss of appetite, gastrointestinal and sexual disorders, polyneuritis, myopathy, and mood changes (including irritability and anger). Effects observed at lower concentrations include neurological problems (encephalopathy, psychomotor and psychological disturbances, polyneuritis, abnormalities in nerve conduction), vision problems (burning eyes, abnormal light reactions, increased ophthalmic pressure), heart problems (increased deaths for heart disease, angina pectoris, high blood pressure), and reproductive problems (increased miscarriages, immobile or deformed sperm), and decreased immune response.
In 2000, the WHO believed that health harms were unlikely at levels below 100 μg/m3, and set this as a guideline level. Carbon sulfide can be smelled at levels above 200 μg/m3, and the WHO recommended a sensory guideline of below 20 μg/m3. Exposure to carbon disulfide is well-established to be harmful to health in concentrations at or above 30 mg/m3 Changes in the function of the central nervous system have been observed at concentrations of 20-25 mg/m3. There are also reports of harms to health at 10 mg/m3, for exposures of 10-15 years, but the lack of good data on past exposure levels make the association of these harms with concentrations of 10 mg/m3 findings uncertain. The measured concentration of 10 mg/m3 may be equivalent to a concentration in the general environment of 1 mg/m3.
The primary source of carbon disulfide in the environment is rayon factories. Most global carbon disulfide emissions come from rayon production, as of 2008. Other sources include the production of cellophane, carbon tetrachloride, carbon black, and sulfur recovery. Carbon disulfide production also emits carbon disulfide.
As of 2004[update], about 250g of carbon disufide is emitted per kilogram of rayon produced. About 30g of carbon disufide is emitted per kilogram of carbon black produced. About 0.341 g of carbon disufide is emitted per kilogram of sulfur recovered.
Japan has reduced carbon disulfide emissions per kilogram of rayon produced, but in other rayon-producing countries, including China, emissions are assumed to be uncontrolled (based on global modelling and large-scale free-air concentration measurements). Rayon production is steady or decreasing except in China, where it is increasing, as of 2004[update]. Carbon black production in Japan and Korea uses incinerators to destroy about 99% of the carbon disulfide that would otherwise be emitted. When used as a solvent, Japanese emissions are about 40% of the carbon disulfide used; elsewhere, the average is about 80%.
Most rayon production uses carbon sulfide. One exception is rayon made using the lyocell process, which uses a different solvent; as of 2018[update] the lyocell process is not widely used, because it is more expensive than the viscose process. Cupro rayon also does not use carbon disulphide.
Industrial workers working with carbon disulfide are at high risk. Emissions may also harm the health of people living near rayon plants.
Concerns about carbon disulfide exposure have a long history. Around 1900, carbon disulfide came to be widely used in the production of vulcanized rubber. The psychosis produced by high exposures was immediately apparent (it has been reported with 6 months of exposure). One infamous rubber factory put bars on its windows so that the workers would not jump out to their deaths. Its use in the US as a heavier-than-air burrow poison for Richardson's ground squirrel also lead to reports of psychosis. No systematic medical study of the issue was published, and knowledge was not transferred to the rayon industry.
The first large epidemiological study of rayon workers was done in the US in the late 1930s, and found fairly severe effects in 30% of the workers. Data on increased risks of heart attacks and strokes came out in the 1960s. Courtaulds, a major rayon manufacturer, worked hard to prevent publication of this data in the UK. Average concentrations in sampled rayon plants were reduced from about 250 mg/m3 in 1955-1965 to about 20-30 mg/m3 in the 1980s (US figures only?[United States-centric]). Rayon production has since largely moved to the developing world, especially China, Indonesia and India.
In 1796, the German chemist Wilhelm August Lampadius (1772–1842) first prepared carbon disulfide by heating pyrite with moist charcoal. He called it "liquid sulfur" (flüssig Schwefel). The composition of carbon disulfide was finally determined in 1813 by the team of the Swedish chemist Jöns Jacob Berzelius (1779–1848) and the Swiss-British chemist Alexander Marcet (1770–1822). Their analysis was consistent with an empirical formula of CS2.
in 1915,...[of 16] carbon disulfide poisoning cases....one worker had been briefly committed to an asylum and several others had experienced nervous system complaints...
|Wikimedia Commons has media related to Carbon disulfide.|
|Wikisource has the text of the 1911 Encyclopædia Britannica article "Carbon Bisulphide".|