The cartellino appears in Italian Renaissance painting from the 15th century into the 16th century, and particularly in painting from Venice and the Veneto from the 1470s to the 1520s. One of the first cartellini appears on the Tarquinia Madonna by Filippo Lippi, painted in 1437. Other early examples include Andrea Mantegna's 1448 painting of St Mark, and Marco Zoppo's Wimborne Madonna of c.1455. Later examples include Carlo Crivelli's c.1480 Lenti Madonna, Giovanni Bellini's 1501–1502 Portrait of Doge Leonardo Loredan and Jacopo de' Barbari's 1504 Still-Life with Partridge and Gauntlets. The cartellino fell out of fashion as artists desired to be known directly from the virtuosic quality of their work, not as craftsmen with a workshop whose work was identified by their name on a label. By 1548, a character in Paolo Pino's Dialogo di pittura was describing the cartellino as a laughable thing. However, there are several cartellini in Hans Holbein the Younger's Portrait of Georg Giese from 1532, and Francisco de Zurbarán included cartellini in about a fifth of his autograph works, including his 1628 painting of Saint Serapion.

In her 2009 PhD thesis, Kandice Rawlings distinguishes the cartellino from other written element including in a painting, such as depictions of inscriptions in stone or on wooden plaques, or writing in books held by subjects, or on streamers or banderoles. Other contemporary terms that were used for the same device include letterina, cartucce, and bolletta – that is, small letter, cartouche, or label. Despite the similarity of the word, there is little evidence of any connection with the cardellino (goldfinch, a symbol of Christ's Passion).

Rawlings documents 412 Italian paintings with cartellini, almost all religious subject or portraits. Early examples are connected with Padua, but about three quarters were painted by artists trained or active in Venice and the Veneto. About three quarters were painted between 1470 and 1530, with the largest number in the first decade of the 16th century. About four fifths contain the artist's signature; a third include a date, often alongside a signature. In addition, Rawlinges identifies another 74 paintings from outside Italy that include cartellini, principally from Germany (mainly Albrecht Dürer in the early 16th century), England (mainly Holbein in the mid-1500s), and Spain (mainly El Greco in the late 16th and early 17th century, Velázquez in the 1630s, and Zurbarán as late as the 1660).

The cartellino had a knowing revival in Diego Rivera's 1915 Zapatista Landscape.

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  Filippo Lippi, Madonna of Tarquinia, 1437
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  Andrea Mantegna, St Mark, 1448
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  Marco Zoppo, Wimborne Madonna, c.1455
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  Carlo Crivellia, Lenti Madonna, c.1480
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  Giovanni Bellini, Portrait of Doge Leonardo Loredan, 1501-2
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  Jacopo de' Barbari, Still-Life with Partridge and Gauntlets, 1504
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  Francisco de Zurbarán, Saint Serapion, 1628
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  Diego Rivera, Zapatista Landscape, 1915

• Museum label
• Musca depicta

• Cartellino, Glossary, National Gallery
• Ostrow, Steven F. (2017). "Zurbarán's 'Cartellini': Presence and the 'Paragone'". Art Bulletin. 99 (1): 67–96. JSTOR 44973137.
• Rawlings, Kandice (2009). Liminal Messages: the cartellino in Italian Renaissance painting (PhD). New Brunswick: Rutgers University.