Cenegermin, sold under the brand name Oxervate, also known as recombinant human nerve growth factor (rhNGF), is a recombinant form of human nerve growth factor (NGF). In July 2017, it was approved in the European Union as an eye drop formulation for the treatment of moderate or severe neurotrophic keratitis in adults.[5][1]
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Trade names | Oxervate |
Other names | cenegermin-bkbj, Recombinant human nerve growth factor; rhNGF; human beta-nerve growth factor (beta-NGF)-(1-118) peptide (non-covalent dimer) produced in Escherichia coli[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a619001 |
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Routes of administration | Ophthalmic |
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Formula | C583H908N166O173S8 |
Molar mass | 13267.15 g·mol−1 |
As a recombinant form of NGF, cenegermin is a peripherally selective agonist of the TrkA and LNGFR (p75NTR) which must be administered parenterally.[6]
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[7]
It was developed by Anabasis Pharma, Dompé Farmaceutici, and Ospedale San Raffaele.[6]
In addition to neurotrophic keratitis, cenegermin is also under development for the treatment of dry eyes, retinitis pigmentosa, and glaucoma.[6]