Clark was born in 1875 to Edward Perkins Clark and Catharine Pickens Upson.^[1] Throughout his life he was the author of many books on a variety of subjects. Among them was the history of West Indies by Antonio Vázquez de Espinosa translated into English,^[2] and the modern history of Romania.^[3]

He also collaborated with the American School of Classical Studies in Rome, where he held a directory of Classical Studies and Archaeology since 1910. He died in 1960.

• "The Text Tradition of Ammianus Marcellinus", 1904
• "Greater Roumania", Dodd, Mead and Company, 1922. Chapter X
• "Bessarabia, Russia and Roumania on the Black Sea", Dodd, Mead and Company, 1927. Electronic Text Archive

• Charles Upson Clark at the Database of Classical Scholars
• Steven Foster, The Badianus Manuscript: The First Herbal from the Americas, 1992
• Azcatitlan Codex
• Bio info^{[permanent dead link]}
• El Consejo Real y Supremo de las Indias: Su historia, organizacion, y labor administrativo hasta la terminacion de la Casa de Austria
• The Birth of the Romanian State
• Society of Fellows, American Academy in Rome