Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.[1][2][3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.[1][2][3] In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties.[4][5] It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.[6][7][8]
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AHFS/Drugs.com | International Drug Names |
MedlinePlus | a682619 |
Routes of administration | Oral |
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ECHA InfoCard | 100.001.315 |
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Formula | C18H21ClN2 |
Molar mass | 300.83 g·mol−1 |
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