Chlorphenoxamine Knowpia

Chlorphenoxamine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, topical
ATC code	D04AA34 (WHO) R06AA06 (WHO);
Pharmacokinetic data
Bioavailability	Well absorbed
Metabolism	Likely liver
Excretion	kidney
Identifiers
	IUPAC name {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine;
CAS Number	77-38-3 562-09-4;
PubChem CID	6475;
DrugBank	DB09007 ;
ChemSpider	6230 ;
UNII	3UVD77BP8R;
KEGG	D07198 ;
ChEMBL	ChEMBL2110774 ;
CompTox Dashboard (EPA)	DTXSID5022805 ;
ECHA InfoCard	100.115.538
Chemical and physical data
Formula	C18H22ClNO
Molar mass	303.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C;
	InChI InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 ; Key:KKHPNPMTPORSQE-UHFFFAOYSA-N ;
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Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic^[1] and antiparkinsonian^[2] agent. It is an analog of diphenhydramine.^[3]

References edit

^ Bazex A, Dupre A, Christol B (1963). "[Trial treatment of urticaria with chlorphenoxamine]". Clinique. 58: 447–50. PMID 13967113.
^ Uldall PR, Walton JN, Newell DJ (June 1961). "Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial". British Medical Journal. 1 (5240): 1649–52. doi:10.1136/bmj.1.5240.1649. PMC 1954253. PMID 13779077.
^ Arnold H, Brock N, Kuhas E, Lorenz D (January 1954). "Beitrag Zur Wirkung Von Antihistamin-Substanzen. 1. Chemische Konstitution Und Pharmakologische Wirkung in Der Gruppe Der Basischen Benzhydrylaether" [Contribution to the Effect Of Antihistamine Substances. 1. Chemical constitution and pharmacological activity in the group of basic benzhydrylethers]. Arzneimittel-Forschung [Drug Research] (in German). 4 (3): 189–94. PMID 13159698.

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	D04AA34 (WHO) R06AA06 (WHO)
Pharmacokinetic data
Bioavailability	Well absorbed
Metabolism	Likely liver
Excretion	kidney
Identifiers
IUPAC name {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
CAS Number	77-38-3^Y 562-09-4
PubChem CID	6475
DrugBank	DB09007^N
ChemSpider	6230^Y
UNII	3UVD77BP8R
KEGG	D07198^Y
ChEMBL	ChEMBL2110774^N
CompTox Dashboard (EPA)	DTXSID5022805
ECHA InfoCard	100.115.538
Chemical and physical data
Formula	C₁₈H₂₂ClNO
Molar mass	303.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C
InChI InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3^Y Key:KKHPNPMTPORSQE-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)