Chromosome 18 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 18 spans about 80 million base pairs (the building material of DNA) and represents about 2.5 percent of the total DNA in cells.
Chromosome 18 | |
---|---|
Features | |
Length (bp) | 80,542,538 bp (CHM13) |
No. of genes | 261 (CCDS)[1] |
Type | Autosome |
Centromere position | Submetacentric[2] (18.5 Mbp[3]) |
Complete gene lists | |
CCDS | Gene list |
HGNC | Gene list |
UniProt | Gene list |
NCBI | Gene list |
External map viewers | |
Ensembl | Chromosome 18 |
Entrez | Chromosome 18 |
NCBI | Chromosome 18 |
UCSC | Chromosome 18 |
Full DNA sequences | |
RefSeq | NC_000018 (FASTA) |
GenBank | CM000680 (FASTA) |
The following are some of the gene count estimates of human chromosome 18. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[4]
Estimated by | Protein-coding genes | Non-coding RNA genes | Pseudogenes | Source | Release date |
---|---|---|---|---|---|
CCDS | 261 | — | — | [1] | 2016-09-08 |
HGNC | 262 | 138 | 241 | [5] | 2017-05-12 |
Ensembl | 268 | 608 | 247 | [6] | 2017-03-29 |
UniProt | 276 | — | — | [7] | 2018-02-28 |
NCBI | 285 | 432 | 304 | [8][9][10] | 2017-05-19 |
The following is a partial list of genes on human chromosome 18. For complete list, see the link in the infobox on the right.
The following diseases are some of those related to genes on chromosome 18:
Chr. | Arm[17] | Band[18] | ISCN start[19] |
ISCN stop[19] |
Basepair start |
Basepair stop |
Stain[20] | Density |
---|---|---|---|---|---|---|---|---|
18 | p | 11.32 | 0 | 159 | 1 | 2,900,000 | gneg | |
18 | p | 11.31 | 159 | 430 | 2,900,001 | 7,200,000 | gpos | 50 |
18 | p | 11.23 | 430 | 526 | 7,200,001 | 8,500,000 | gneg | |
18 | p | 11.22 | 526 | 685 | 8,500,001 | 10,900,000 | gpos | 25 |
18 | p | 11.21 | 685 | 1035 | 10,900,001 | 15,400,000 | gneg | |
18 | p | 11.1 | 1035 | 1290 | 15,400,001 | 18,500,000 | acen | |
18 | q | 11.1 | 1290 | 1561 | 18,500,001 | 21,500,000 | acen | |
18 | q | 11.2 | 1561 | 1847 | 21,500,001 | 27,500,000 | gneg | |
18 | q | 12.1 | 1847 | 2229 | 27,500,001 | 35,100,000 | gpos | 100 |
18 | q | 12.2 | 2229 | 2436 | 35,100,001 | 39,500,000 | gneg | |
18 | q | 12.3 | 2436 | 2755 | 39,500,001 | 45,900,000 | gpos | 75 |
18 | q | 21.1 | 2755 | 3153 | 45,900,001 | 50,700,000 | gneg | |
18 | q | 21.2 | 3153 | 3392 | 50,700,001 | 56,200,000 | gpos | 75 |
18 | q | 21.31 | 3392 | 3519 | 56,200,001 | 58,600,000 | gneg | |
18 | q | 21.32 | 3519 | 3663 | 58,600,001 | 61,300,000 | gpos | 50 |
18 | q | 21.33 | 3663 | 3758 | 61,300,001 | 63,900,000 | gneg | |
18 | q | 22.1 | 3758 | 4077 | 63,900,001 | 69,100,000 | gpos | 100 |
18 | q | 22.2 | 4077 | 4204 | 69,100,001 | 71,000,000 | gneg | |
18 | q | 22.3 | 4204 | 4411 | 71,000,001 | 75,400,000 | gpos | 25 |
18 | q | 23 | 4411 | 4650 | 75,400,001 | 80,373,285 | gneg |