Cinitapride

Summary

Cinitapride (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiemetic agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain.[1][2] It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.[3][4]

Cinitapride
Clinical data
Trade namesCintapro, Pemix
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
CAS Number
  • 66564-14-5 checkY
PubChem CID
  • 68867
DrugBank
  • DB08810 checkY
ChemSpider
  • 62099 checkY
UNII
  • R8I97I2L24
KEGG
  • D07700 checkY
ChEMBL
  • ChEMBL2104523 ☒N
Chemical and physical data
FormulaC21H30N4O4
Molar mass402.495 g·mol−1
ChiralityRacemic mixture
  • InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26) checkY
  • Key:ZDLBNXXKDMLZMF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Uses edit

It is indicated for the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying. It may be also used in the management of nausea and vomiting.

See also edit

References edit

  1. ^ Robert M, Salvà M, Segarra R, et al. (July 2007). "The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole". Drug Metabolism and Disposition. 35 (7): 1149–56. doi:10.1124/dmd.106.010835. PMID 17437965. S2CID 1284844.
  2. ^ Fernández AG, Massingham R (January 1985). "Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs". Life Sciences. 36 (1): 1–14. doi:10.1016/0024-3205(85)90280-2. PMID 2981378.
  3. ^ Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V (April 1997). "Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds". Pharmacology. 54 (4): 193–202. doi:10.1159/000139487. PMID 9211565.
  4. ^ Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V (March 1998). "Effects of cinitapride on gastric ulceration and secretion in rats". Inflammation Research. 47 (3): 131–6. doi:10.1007/s000110050301. PMID 9562338. S2CID 25620004. Archived from the original on 1999-08-27. Retrieved 2010-02-27.