A city region in the United Kingdom may refer to:

• Combined authorities and combined county authorities in England, some styled as "city regions"
• Glasgow City Region, a geographic area of Scotland
• Greater Brighton City Region, an area in the south of England
• Leeds City Region, a local enterprise partnership in West Yorkshire
• Liverpool City Region, a combined authority area in North West England
• Local enterprise partnerships in England, some styled as "city regions"
• Regional economic boards in Wales, some styled as "city regions"