Colomba may refer to:

• Colomba, Quetzaltenango, a municipality in Guatemala
• Colomba (surname)
• Colomba Fofana (born 1977), French triple jumper
• Colomba Gabriel (1858–1926), Ukrainian Roman Catholic professed religious and founder of the Benedictine Sisters of Charity
• "Colomba" (novella), a short story by Prosper Mérimée first published in 1840
• Colomba (1918 film), a German silent film
• Colomba (1933 film), a French film directed by Jacques Séverac
• Colomba (1948 film), a French film directed by Émile Couzinet
• Colomba, an opera by Alexander MacKenzie