The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates.[1]
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Preferred IUPAC name
N-(5-Chloropyridin-2-yl)-N-(methanesulfonyl)methanesulfonamide | |
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ECHA InfoCard | 100.157.321 |
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CompTox Dashboard (EPA)
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Properties | |
C7H3ClF6N2O4S2 | |
Molar mass | 392.67 g·mol−1 |
Appearance | White solid |
Melting point | 45 °C (113 °F; 318 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It was first reported in 1992 by Daniel Comins.[2] The vinyl triflates prepared are useful as substrates in the Suzuki reaction.[3]