Corticorelin (INN, trade name Xerecept) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).[1]
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Elimination half-life | 9 minutes |
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Formula | C208H344N60O63S2 |
Molar mass | 4757.52 g·mol−1 |
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The corticorelin stimulation test helps to differentiate between the causes for adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to distinguish a pituitary source of excessive ACTH secretion from a different source.
The most common side effects (in 1% to 10% of patients) are transient dysosmia and dysgeusia (distortion of the sense of smell and taste), as well as a sensation of warmth. About 0.1 to 1% of patients experience hypersensitivity, hypotension (lowering of blood pressure), tachycardia (increased heart rate), flush, dyspnoea (breathing difficulties), a cold sensation in the throat, the urge to urinate, and dizziness. Pituitary apoplexy has been reported in patients with pituitary tumours.[2]
The effects of corticorelin are reduced by corticosteroids, antihistamines, antiserotonergics and oxytocin. They are amplified by vasopressin and its analogues.[2]