Cristoforo Colombo (1451–1506) was an Italian explorer better known as "Christopher Columbus".

Cristoforo Colombo may also refer to:

• Cristoforo Colombo (opera), an 1892 opera in four acts and an epilogue by Italian Alberto Franchetti
• SS Cristoforo Colombo, an Italian ocean liner built in the 1950s
• Italian corvette Cristoforo Colombo (1892), an Italian unprotected corvette
• Italian school ship Cristoforo Colombo (1926), an Italian tall ship, later Dunay in the Soviet Navy
• Via Cristoforo Colombo, a road in Rome named for Christopher Columbus
• Genoa Cristoforo Colombo Airport, airport of Genoa, Italy