Curtis Jackson or 50 Cent (born 1975), is an American rapper.

Curtis Jackson may also refer to:

• Curtis Jackson (gridiron football) (born 1973), American football wide receiver
• Curtis Jackson (cricketer) (born 1967), Bermudian cricketer
• Curtis "C.J." Jackson, fictional character from the American television series, The White Shadow
• Curtis Jackson, character in American Ninja