Cyanopindolol

Summary

Cyanopindolol is a drug related to pindolol which acts as both a β1 adrenoceptor antagonist and a 5-HT1A receptor antagonist. Its radiolabelled derivative iodocyanopindolol has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1]

Cyanopindolol
Skeletal formula of cyanopindolol
Space-filling model of the cyanopindolol molecule
Clinical data
ATC code
  • none
Identifiers
  • (RS)-4-[3-(tert-Butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
CAS Number
  • 69906-85-0 checkY
PubChem CID
  • 155346
IUPHAR/BPS
  • 132
ChemSpider
  • 136847 ☒N
UNII
  • 4K0SD5SNFS
ChEMBL
  • ChEMBL378501 ☒N
PDB ligand
  • P32 (PDBe, RCSB PDB)
Chemical and physical data
FormulaC16H21N3O2
Molar mass287.363 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
  • N#CC1=CC2=C(OCC(CNC(C)(C)C)O)C=CC=C2N1
  • InChI=1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3 ☒N
  • Key:QXIUMMLTJVHILT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

References edit

  1. ^ Hoyer D, Engel G (1983). "Binding of 125I-cyanopindolol to beta-1-adrenoceptors in a high and low affinity state". Journal of Receptor Research. 3 (1–2): 45–59. doi:10.3109/10799898309041922. PMID 6304308.