DNA2L Knowpia

DNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EAY
Identifiers
Aliases	DNA2, DNA2L, hDNA replication helicase/nuclease 2
External IDs	OMIM: 601810 MGI: 2443732 HomoloGene: 6124 GeneCards: DNA2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,472,121 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,809,964 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; right lobe of liver; ; rectum; ; spongy bone; ; stromal cell of endometrium; ; thymus; ; bone marrow cells; ; right lung; ; appendix;
	Top expressed in
	primitive streak; ; abdominal wall; ; otic placode; ; medial ganglionic eminence; ; secondary oocyte; ; somite; ; vas deferens; ; maxillary prominence; ; hair follicle; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; 4 iron, 4 sulfur cluster binding; nucleotide binding; helicase activity; iron-sulfur cluster binding; metal ion binding; 5'-flap endonuclease activity; DNA helicase activity; ATPase activity; protein binding; catalytic activity; 5'-3' DNA helicase activity; nuclease activity; endonuclease activity; site-specific endodeoxyribonuclease activity, specific for altered base; hydrolase activity; ATP binding; single-stranded DNA helicase activity; RNA binding;
Cellular component	nucleoplasm; gamma DNA polymerase complex; mitochondrial nucleoid; nucleus; mitochondrion; cytoplasm;
Biological process	mitotic telomere maintenance via semi-conservative replication; mitochondrial DNA repair; nucleic acid phosphodiester bond hydrolysis; DNA double-strand break processing; mitochondrial DNA replication; cellular response to DNA damage stimulus; DNA replication checkpoint signaling; positive regulation of DNA replication; metabolism; base-excision repair; DNA replication, removal of RNA primer; DNA replication; telomere maintenance; DNA duplex unwinding; DNA repair; G-quadruplex DNA unwinding; t-circle formation; telomere maintenance via semi-conservative replication; DNA replication, Okazaki fragment processing; replication fork reversal; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	1763
	327762
	ENSG00000138346
	ENSMUSG00000036875
	P51530
	Q6ZQJ5
	NM_001080449
	NM_177372
	NP_001073918
	NP_796346
	Wikidata
View/Edit Human	View/Edit Mouse

DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.^[5]^[6]^[7] Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138346 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036875 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–10. doi:10.1006/geno.1996.0581. PMID 8938459.
^ Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". J Biol Chem. 281 (50): 38555–64. doi:10.1074/jbc.M604925200. PMID 17032657.
^ "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".
^ Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.

Further reading edit

Masuda-Sasa T, Imamura O, Campbell JL (2006). "Biochemical analysis of human Dna2". Nucleic Acids Res. 34 (6): 1865–75. doi:10.1093/nar/gkl070. PMC 1428797. PMID 16595800.
Kim JH, Kim HD, Ryu GH, et al. (2006). "Isolation of human Dna2 endonuclease and characterization of its enzymatic properties". Nucleic Acids Res. 34 (6): 1854–64. doi:10.1093/nar/gkl102. PMC 1428795. PMID 16595799.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138346 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036875 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8938459-5] Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–10. doi:10.1006/geno.1996.0581. PMID 8938459.

[pmid17032657-6] Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". J Biol Chem. 281 (50): 38555–64. doi:10.1074/jbc.M604925200. PMID 17032657.

[entrez-7] "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".

[Mimitou_2009-8] Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.

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Summary

References edit

Further reading edit