DZME started its broadcast on June 15, 1968 under the ownership of the Luison family, led by Atty. Joey Luison, Jr.. During the first ten years of operations, the station operated on the frequency of 1540 kHz until November 1978, when it was reassigned on the current frequency of 1530 kHz.

In October 1987, the then former president Corazon Aquino, through the National Telecommunications Commission, ordered to shut down DZME for a few months, on a ground that the national security is at grave risk. The station gained notoriety for airing controversial right-wing propaganda and commentary programs that were critical of Mrs. Aquino's Administration, during a series of unsuccessful coup attempts to topple the administration by the right-wing rebel groups and other enemies of the state, but it returned on the air thereafter on January 1, 1988.^[4]

In 1996, a new group of investors, including former Surigao del Sur Congressman Prospero Pichay Jr., took over the assets and properties of the radio station from the Luison family.

In 2004, DZME adopted the Radyo Uno brand, coinciding with the acquisition of its Harris transmitter.

In 2009, as part of its plan to expand operations, DZME transferred to Victory Central Mall in Monumento, Caloocan from its long-time former site in Roosevelt Avenue in Quezon City, which currently houses a branch of Bank of the Philippine Islands. Regional affiliates had already developed to bolster its nationwide presence, which gave birth to Like Radio.

From November 2013 to January 2014, some its programs (except for news casts) were temporarily postponed and replaced by music fillers due to technical upgrades & the transfer of the studios to OMM-Citra Building in Ortigas Center, Pasig.

After Holy Week of 2015, the Radyo Uno brand was dropped. In the last quarter of 2016, DZME enhanced its overall programming line-up and revitalizing its news division, as well as the launch of its new programs, with a few of the station's old programs retained.

Recently, DZME was being recognized by award-giving bodies for its responsible and balanced programming including the Best Teleradyo Station of the Year of the World Class Excellence Japan Awards, Most Outstanding Local Radio Station in National Category at the Asian Sterling Business Awards and the Most Trusted Radio Station in National Category in the Legacy Awards and was also among the Top 10 Mega Manila AM stations in the ratings released by Kantar-KBP and Nielsen. In May 2023, the station slowly revived its Radyo Uno brand.