Darusentan (LU-135252; HMR-4005) is an endothelin receptor antagonist.[1] Gilead Colorado, a subsidiary of Gilead Sciences,[2] under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension.
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Routes of administration | Oral |
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Metabolism | Hepatic |
Elimination half-life | 12.5 hours |
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ECHA InfoCard | 100.126.841 |
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Formula | C22H22N2O6 |
Molar mass | 410.426 g·mol−1 |
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In June 2003, Myogen licensed the compound from Abbott for its application in the cancer field.[3]
In May 2007, a randomized, double-blind, active control, parallel assignment, safety and efficacy phase III trial was initiated in subjects who had completed the maintenance period of the DAR-312 study, but was terminated because the study did not reach its primary endpoints.[4]