Lafuente first penciled such series as Phénix and Kabur (written by Jean-Marc Lofficier) for Hexagon Comics, then was discovered by Marvel Editor C.B. Cebulski at the Dublin City Comic Con during the editor's self-named talent search ChesterQuest", though the artist's official website displays professional work dated much earlier than this. His first work for Marvel was doing the layouts and coloring for Spider-Man Family #2, Published in 2007. His first major work, however, was providing the pencils/inks for Kathryn Immonen's 2008-2009 Hellcat mini-series.^[2] After collaborating with writer Brian Michael Bendis on an Ultimate Spider-Man Annual in 2008, he was picked as the regular artist for that series' 2009 relaunch, which debuted in August 2009.^[1] He took over New Mutants as the regular artist, starting on issue 29, which was a tie-in to the 2011 "Fear Itself" storyline.

On April 9, 2011 Lafuente was one of 62 comics creators who appeared at the IGN stage at the Kapow! convention in London to set two Guinness World Records, the Fastest Production of a Comic Book, and Most Contributors to a Comic Book. With Guinness officials on hand to monitor their progress, writer Mark Millar began work at 9am scripting a 20-page black and white Superior comic book, with Lafuente and the other artists appearing on stage throughout the day to work on the pencils, inks, and lettering, including Dave Gibbons, Frank Quitely, John Romita Jr., Jock,^[3] Doug Braithwaite, Ian Churchill, Olivier Coipel, Duncan Fegredo, Simon Furman, John McCrea, Sean Phillips and Liam Sharp,^[4] who all drew a panel each, with regular Superior artist Leinil Yu creating the book's front cover. The book was completed in 11 hours, 19 minutes, and 38 seconds, and was published through Icon on November 23, 2011, with all royalties being donated to Yorkhill Children's Foundation.^[3]

In January 2015 it was announced that Kieron Gillen, Jim Rossignol and David Lafuente were working on a creator-owned series for Image Comics titled "The Ludocrats."^[5] Due to schedule issues, the art ended up being done by Jeff Stokely.^[6]

David Lafuente was exclusive to Valiant Comics in 2015 and 2016 ^[7] and was the regular artist on A&A: The Adventures Of Archer & Armstrong. In 2019 drew the Amazing Spider-Man Annual starring Spider-Ham, written by Jason Latour, later moved to DC Comics to work on Superman with frequent collaborator Brian Michael Bendis.^[8]

As of 2022, Lafuente works as video-game concept artist for Atmos.

David Lafuente has an active YouTube presence in his own channel and in the Streaming de Dibujantes channel with David Lopez (artist).

Covers only edit

• David Lafuente at the Grand Comics Database

• Twitter account
• YouTube channel
• David Lafuente at the Comic Book DB (archived from the original)
• Comicvine
• Tebeosfera