David Mack may refer to:

• David Mack (police officer) (born 1961), professional runner, police officer, and bank robber
• David Mack (politician) (born 1953), South Carolina politician
• David Mack (rower), American lightweight rower
• David Alan Mack, American television scriptwriter and novelist
• David Lyle Mack, American diplomat
• David S. Mack (born 1941), American businessman
• David W. Mack (born 1972), American comic book artist and writer