David or Dave Shapiro may refer to:

• Dave Shapiro (drummer), performer of Cinematic Sunrise
• David C. Shapiro (1925–1981), American dentist and politician
• David I. Shapiro (1928–2009), attorney
• David L. Shapiro (born 1943), American psychologist
• David Shapiro (bass player) (1952–2011), American jazz musician
• David Shapiro (composer) (born 1969), for instance "Sumptuous Planet" and "It is Time" performed by the American choral ensemble The Crossing
• David Shapiro (economist) (born 1946), American economist
• David Shapiro (filmmaker), e.g. Keep the River on Your Right: A Modern Cannibal Tale (2000)
• David Shapiro (music producer), for example for the Charlie Rose TV series
• David Shapiro (pianist), performer of the New York Percussion Trio
• David Shapiro (poet) (born 1947), American poet, literary critic and art historian
• Dr. Cat (born David Shapiro), president, co-founder, executive producer and creative director of Dragon's Eye Productions
• J. David Shapiro (or J.D. Shapiro, born 1969), American filmmaker and stand-up comedian
• Shel Shapiro, born Norman David Shapiro, musician sometimes credited as David Shapiro (e.g. as co-author of the "Let's Live for Today" song)