David Wilkins may refer to:

• David H. Wilkins (born 1946), American politician and ambassador
• David Wilkins (sailor) (born 1950), Irish sailor
• David Wilkins (orientalist) (1685–1745), Prussian orientalist
• David B. Wilkins, American law professor
• David E. Wilkins, Lumbee political scientist and scholar of Native politics
• Dave Wilkins (1914–1990), jazz trumpeter from Barbados