Decyl(triphenyl)phosphonium (DTPP) is the organophosphorus cation with the formula C10H21P(C6H5)3+. It is a lipophilic quaternary phosphonium cation. It forms the basis for many mitochondrial-targeted drugs, including MitoQ, MitoE, and SkQ. It binds to the mitochondrial matrix by insertion into the inner membrane.[1][2] DTPP itself can cause mitochondrial swelling in kidney tissue, an action possibly related to increased membrane permeability.[3]
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Preferred IUPAC name
Dodecyltri(phenyl)phosphanium | |
Other names
Dodecyltriphenylphosphonium, C12TPP(+), DTPP
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Identifiers | |
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3D model (JSmol)
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ChEBI |
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ChEMBL |
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ChemSpider |
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PubChem CID
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UNII |
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CompTox Dashboard (EPA)
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Properties | |
C30H40P+ | |
Molar mass | 431.623 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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