Sea water has a long history of therapeutic use, referred to as "Thalassotherapy" it originates from the Greek word "Thalassa." Both Greeks and Romans used the therapeutic effects of seawater for relaxation, regeneration, and stimulation. Books on the healing power of seawater first appeared in the 17th century, and until the early 20th century, seaside holidays were considered both therapeutic and recreational.

In 1897, René Quinton published the first comprehensive scientific thesis advocating the medical use of seawater in his book, Seawater Organic Matrix, 1904. He discovered the similarity between the nutrient profile in microalgae ocean water and our blood nutrient profile. He noted that the ratios of minerals in both fluids were similar, with the exception of sodium chloride, which he adjusted. Quinton selected seawater from regions that also contained microalgae.

There are three distinctly different layers of ocean water - Surface Sea Water, Deep Ocean Water (DOW), and Very Deep Ocean Water. Each layer remains separate and autonomous from the others, moving at different speeds and directions from different kinetic forces and having different temperatures, densities, and life-form statuses.

The surface seawater layer is influenced by sunlight penetration and circulates rapidly in unison with the seasons and wind patterns to a depth of 250 meters. It supports micro and animal life.

The middle layer is DOW, where the water is free of sunlight and life forms. It is characterized not only by its mineral density but cold temperature, cleanliness, and trace elements. DOW is present at depths of between 250 and 1500 meters. This deep ocean current moves very slowly under the influence of density and temperature gradients. The high mineral density is attributed to the depth-related pressure and the change in temperature from 20°C+ at the surface to 8°C at 600 meters depth generates the movement of this layer.

Very deep ocean water has been discovered in a number of troughs in the Atlantic and Pacific Oceans. Depths can range from 1500 meters to 15 kilometers and life forms are supported where volcanic processes bring heat and minerals to the seabed floor.

DOM creation begins when the summer ice melts from both Greenland and the Sub-Arctic region. The melting water collects minerals and trace elements during its journey to the ocean.

The minerals make the water heavier (DOW), so the water naturally sinks to the ocean floor where it commences a 2000-year journey. It flows southwards down the Atlantic Ocean, moves around the African Cape, and then inches north through the Indian Ocean and also into the western Pacific Ocean, first coming close to land in Taiwan, then Okinawa and Hawaii. Here it starts arching back south, towards the Antarctica where the changing seawater temperatures from the summer sun force the deep ocean water to the surface to feed the largest micro and macro food chain on our planet.

The east coast of Taiwan is directly adjacent to one of the largest reservoirs of accessible DOW. The southern islands of Japan and Hawaii also have land access to deep ocean water.

Taiwan´s east coast is ideally located to siphon deep ocean water directly to the surface from the coast. It is then micro-filtered, followed by reverse osmosis to desalinate and concentrate the magnesium and other minerals and trace elements at the expense of sodium chloride.

Over the past 15 years, there have been over 40 new publications establishing DOM as statistically significant with regard to improved cardiovascular and metabolic function. Recent clinical research from Taiwan, Japan, and Korea also shows statistically significant therapeutic health benefits from either topical or oral consumption of DOM.

In 2009, scientists at the National Taiwan Ocean University, Keelung, Taiwan, published the first notable Wistar rat treadmill fatigue study. Researchers used desalinated deep ocean water processed with ultra-filtration and reverse osmosis to increase magnesium levels and hardness. The water was sourced from the east coast of Taiwan. The study showed that the DOM experimental groups were significantly better than the control group with regard to exhausting time and the ratio of lactic acid elimination to lactic acid increment. Summarizing the results, the researchers suggested that endurance, adaptation to exercising load and accelerating the elimination of fatigue in rats could be improved when fed with DOM of higher hardness and quantity.^[4]

In 2014, scientists at Hung Kuang University, Taichung, Taiwan, published a gerbil animal trial, endorsing the findings of the Wistar rat trial and again demonstrating that profiled deep ocean water significantly improved exercise performance in gerbils subjected to treadmill exercise.^[5]

In 2013, researchers at the Department of Sports Sciences, Taipei University conducted a randomized double-blind placebo-controlled cross-over human study to evaluate the effect of DOW on-time recovery from a fatiguing exercise conducted at 30°C. DOM supplementation resulted in the complete recovery of aerobic power within four hours. Muscle power was also elevated above placebo levels within 24 hours of recovery. Increased circulating creatine kinase (CK) and myoglobin, indicators of exercise-induced muscle damage, were completely eliminated by DOM in parallel with attenuated oxidative damage. Researchers concluded that the results provide compelling evidence that DOM contains soluble elements, which can increase human recovery following an exhaustive physical challenge.^[6]

Over the last 11 years, studies show the potential application of DOM for use as a dietary therapy for the prevention and complementary treatment of cardiovascular disease. In 2003, Japanese researchers published their findings regarding the pharmacological activity of DOM directly influencing the serum lipid values of cholesterol-fed rabbits.^[7]

In 2008, a Japanese research group used hypercholesterolemic rabbits to examine changes due to the DOW diet on cardiovascular hemodynamics (blood flow and pressure). Systolic, diastolic, pulse and mean arterial pressures, and total peripheral resistance were significantly lower in the DOW group than in the control group.^[8]

The first human trial of DOM was conducted in Japan in 2008 with 16 male volunteers examining the effect of Nigari (natural salty sea or lake water) standardized on magnesium in a two-way, randomized cross-over study. The healthy subjects were given a fat load test prior to measuring the effect of postprandial (after meal) hyperlipidemia. They found that Mg supplementation reduced and delayed the postprandial serum and chylomicron TAG responses after fat loading. The data indicates that Mg supplementation may contribute to preventing the atherogenic process in healthy subjects.^[9]

In addition, a series of research papers from Taichung University, Taiwan was published. In 2011, mice trials confirmed similar results to the Japanese findings and concluded that electro-dialyzed DOW benefited high-cholesterol dietary mice and recommended that standardized DOM should be pursued as a dietary food ingredient for cardiovascular health.^[10] Similar results at the Taichung Medical University were also published in 2011 for hamsters.^[11]

In 2012, in Taipei, a major human trial with 42 hypercholesterolemic volunteers were randomly divided into three groups: reverse osmotic (RO) water, DOM (Mg: 395 mg/L, hardness 1410ppm), and magnesium-chloride fortified (MCF) water (Mg: 386 mg/L, hardness 1430ppm). Serum low-density lipoprotein-cholesterol (LDL-C) was also decreased by DOM. Further, the total cholesterol levels of subjects in the DOM group were significantly lower than those in the MCF water or RO water groups.^[12]

In 2013, Taichung University researchers published an extended rat trial. The study indicated that 0.1 × DOM, 1 × DOM, and 2 × DOM decreased the systolic and diastolic pressures in spontaneously hypertensive rats in an eight-week experiment. DOM has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. The results demonstrated that DSW significantly suppressed serum cholesterol levels, reduced lipid accumulation in liver tissues, and limited aortic fatty streaks.^[13]

In 2014, Qingdao Ocean University, China, published a paper showing when DOM was added to HepG2 cells, it decreased the lipid contents of hepatocytes through the activation of AMP-activated protein kinase, thus inhibiting the synthesis of cholesterol and fatty acid and recommended further investigation for treatment and prevention of hypolipidemic and other lifestyle-related diseases.^[14]

The DOM research points to it having a possible, positive impact on cardiovascular health. However, research findings from the Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea, also extend the possible dietary use of DOM as a treatment for metabolic syndrome. In 2008, Korean researchers reported DOM could potentially be used as an anti-obesity agent by inhibiting adipocyte differentiation, mediated through the down-regulated expression of adipogenic transcription factors and adipocyte-specific proteins.^[15]

In 2009, the same Korean researchers published a further study on the anti-obesity and anti-diabetic effects of DOM in obese mice. The control group received tap water and the experimental group received DOM of hardness 1000 for 84 days. The DOM-fed group compared to the control group reported a 7% body weight decrease, reduced plasma glucose levels by 35.4%, and a significant increase in glucose disposal after 84 days. The research suggests that the anti-diabetic and anti-obesity activities of DOM were mediated by modulating the expression of diabetes and obesity-specific molecules. Taken together, these results provide a possibility that continuous intake of DOM can be of dietary therapeutic value for the treatment of obesity and diabetes. In 2013, further diabetes-induced mice study was conducted to establish dosage regimes. The researchers concluded that DOM provided a novel activator for glucose uptake.^[16][17]