Del Castillo may refer to:

• Del Castillo (band), a Latin rock band from Texas
• Del Castillo (organist), American cinema organist, theatre organist and composer
• Jorge del Castillo (born 1950), Peruvian lawyer and politician
• Kate del Castillo, Mexican actress
• Mariano del Castillo (born 1949), Filipino judge
• Michel del Castillo (born 1933), French writer
• Pilar del Castillo (born 1952), Spanish politician