Demexiptiline (brand names Deparon, Tinoran) is a tricyclic antidepressant (TCA) used in France for the treatment of depression.[2][3] It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.[4]
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Trade names | Deparon, Tinoran |
Routes of administration | Oral |
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Elimination half-life | 35 hours[1] |
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Formula | C18H18N2O |
Molar mass | 278.355 g·mol−1 |
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The synthesis is similar to that reported for Noxiptiline but also differs in a couple of respects.
The condensation between Dibenzosuberenone [2222-33-5] (1) and hydroxylamine (2) gives the oxime, [1021-91-6] (3). Base catalyzed attachment of the sidechain by reaction with 2-Chloro-N-Methylethanamine [32315-92-7] (4) completed the synthesis of demexiptiline (5).