Born and raised in San Juan, Puerto Rico, Denisse Oller graduated Summa Cum Laude from University of Puerto Rico High School. She attended the University of Puerto Rico, Rio Piedras Campus, where she majored in Finance and minored in French before attending Hunter College in New York City, where she graduated Summa Cum Laude with a bachelor's degree in media studies and a minor in Interpersonal Communications.^[15] Denisse subsequently pursued graduate studies at Seton Hall University^[16] and IESE Business School, University of Navarra, Spain. Oller lived in Madrid, Spain, during her youth before moving permanently to New York City.  

Oller’s family was involved in the history of Puerto Rico.^[17][18] Her first cousin, twice removed, Francisco Oller y Cestero, is the only Latin American painter to have played a role in the development of Impressionism.^[19] One of the most distinguished transatlantic painters of his day, Oller helped transform painting in the Caribbean. Her great-great-grandfather, Dr. Francisco Oller, Chief Surgeon of Spain's Royal Military Hospital in the 1800s, first brought the smallpox vaccine to Puerto Rico during an epidemic on the island.^[20]

Her other interest is healthy cooking. A graduate of the Culinary Education Institute in New York City,^[21] Oller was a guest instructor at the Institute, as well as a chef-collaborator for AARP. She also appeared on Fox Good Day NY, NBC's Today Show,^[22] Martha Stewart Living, Food Network's "Throwdown with Bobby Flay" and CNN en Español, advocating for a healthier lifestyle and food choices for the Latino community.^[23] Oller has repeatedly appeared as a guest chef at Puerto Rico's premiere food festival, Saborea.^[24]

Oller started her career in television journalism at Telemundo NY in 1985 as a news writer^[25] and general assignment reporter. One of her first duties was to cover the Challenger disaster in January 1986. She then took up a National News correspondent position based in New York. Shortly after, Oller was tapped to anchor Univision's "Weekend Edition" newscast, the first Puerto Rican and the first Latina to anchor a US Spanish speaking national news weekend broadcast. She also served as a national correspondent in Los Angeles and New York.^[26]

She won her first Emmy in 1991 for coverage of the Gulf War heroes' arrival in New York.^[27] This honor marked the first time an Emmy was awarded to a Spanish language station (Univision) in New York.

In 1992, Oller relocated to Miami to anchor 'Primera Hora', Telemundo's early morning national news program.^[28][29] Once the show ended, she moved to Washington, DC, as a correspondent for Telemundo National News, and in 1995, she became co-anchor of Telemundo Network's national newscast. Oller's work has been recognized by prominent national journalistic and advocacy institutions such as the Associated Press, the National Organization for Women (NOW),^[30] the American Women in Radio and Television, the Media Institute,^[31] the Emmys, and the Radio Television Digital News Association (RTDNA.) Oller also received the Edward R. Murrow Award for excellence in investigative reporting. Oller is a documentary filmmaker, having won a National Emmy for her investigative work "Hora Cero: Nicaragua in Transition".^[32]

As a field reporter, Oller covered such events as the 9/11 terrorist attacks,^[33] the 1995 Oklahoma City bombings, the 1994 earthquake in Northridge, California, President Clinton's impeachment process, and the historic visit of Pope John Paul II to Cuba,^[34] where she interviewed both dissidents and government officials.^[35]  

In 1999, she returned to New York as co-anchor of the highest-rated newscasts in the tri-state area, Univision-NY News 41, at 6 PM and 11 PM. In November 2007, Oller officially ended her 20-year career in the news^[36] to pursue independent ventures^[37] and establish NEWSWORKS Productions, a multi-platform entity specializing in contemporary lifestyle subjects and current events.

As Vice President of Media Relations and Engagement for SOMOS Community Care – a non-profit network that serves more than one million Medicaid recipients in underserved communities in the Bronx, Brooklyn, Manhattan, and Queens – Oller developed communications and public relations initiatives to advocate for healthcare reform.^[38][39]

From 2005 to 2022, Oller led SOMOS Community Care's DASH (Dietary Approaches to Stop Hypertension) outreach programs on preventive health care and healthier lifestyle choices,^[40] and efforts to improve health literacy as prevention in underserved communities where chronic illnesses such as diabetes, cardiovascular disease, and obesity is prevalent.^[41]

Before SOMOS, Oller worked for a number of non-profit entities. From 2010 to 2016, she was the Executive Director of The Joseph A. Unanue Latino Institute at Seton Hall University, an organization dedicated to supporting Latino students by providing scholarships, educational opportunities, and leadership initiatives.^[42]

Oller is currently working on a book on self-esteem and mental health and continues her work as an influencer.^[43]

• Official website Archived 2009-03-05 at the Wayback Machine