Dexbrompheniramine

Summary

Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine
Clinical data
Trade namesDrixoril, Conex, Dixaphedrine
AHFS/Drugs.comMultum Consumer Information
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life25 hours
Identifiers
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
CAS Number
  • 132-21-8 checkY
PubChem CID
  • 16960
IUPHAR/BPS
  • 7588
DrugBank
  • DB00405 checkY
ChemSpider
  • 16068 checkY
UNII
  • 75T64B71RP
ChEBI
  • CHEBI:59269 checkY
ChEMBL
  • ChEMBL1201287 ☒N
CompTox Dashboard (EPA)
  • DTXSID8022905 Edit this at Wikidata
ECHA InfoCard100.004.595 Edit this at Wikidata
Chemical and physical data
FormulaC16H19BrN2
Molar mass319.246 g·mol−1
3D model (JSmol)
  • Interactive image
  • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
  • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

Interactions edit

MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Drinking alcohol can increase side effects of dexbrompheniramine.

References edit

  1. ^ Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of International Medical Research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306. S2CID 39205584.

External links edit

  •   Media related to Dexbrompheniramine at Wikimedia Commons