Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
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Trade names | Chlor-trimeton, Polaramine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682543 |
Routes of administration | Oral, Intravenous |
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ECHA InfoCard | 100.042.779 |
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Formula | C16H19ClN2 |
Molar mass | 274.79 g·mol−1 |
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It came into medical use in 1959 and was patented in 1962.[3]
Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]