DiPT Knowpia

DiPT
Clinical data
Trade names	Dipt.
Other names	N,N-Diisopropyltryptamine, DiPT
ATC code	none;
Legal status
Legal status	AU: Unscheduled; CA: Unscheduled; DE: NpSG (Industrial and scientific use only); UK: Class A; US: Unscheduled;
Identifiers
	IUPAC name 3-[2-(Diisopropylamino)ethyl]indole;
CAS Number	14780-24-6 ;
PubChem CID	26903;
ChemSpider	25060 ;
UNII	E352B01VMH;
ChEBI	CHEBI:48286 ;
CompTox Dashboard (EPA)	DTXSID80163804 ;
Chemical and physical data
Formula	C16H24N2
Molar mass	244.382 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)N(CCc1c[nH]c2ccccc12)C(C)C;
	InChI InChI=1S/C16H24N2/c1-12(2)18(13(3)4)10-9-14-11-17-16-8-6-5-7-15(14)16/h5-8,11-13,17H,9-10H2,1-4H3 ; Key:ZRVAAGAZUWXRIP-UHFFFAOYSA-N ;
	(verify)

Diisopropyltryptamine (/ˌdaɪˌaɪsoʊˌproʊpɪlˈtrɪptəmiːn/; also known as N,N-diisopropyltryptamine or DiPT) is a psychedelic hallucinogenic drug of the tryptamine family that has a unique effect. While the majority of hallucinogens affect the visual sense, DiPT is primarily aural.^[1]

Hallucinogenic properties edit

DiPT's effects are primarily aural. At lower doses, Alexander Shulgin reported effects similar to a flanging or a phase shift. At medium and higher dosages, the effect of DiPT is typically a radical shift downward in perceived pitch. This shift tends to be nonlinear, in that the shift downwards varies in relation to the initial pitch. This can produce bizarre sounds and render music disharmonious.^[1] There has been an experiment involving subjects with perfect pitch, the goal of which was to determine whether the pitch difference is truly distortive or linear, the results of which indicated that there is no clear relationship between perceived pitch and actual pitch.^[1] Aside from these, the most prevalent non-auditory effect is inner ear pressure (which has been painful in some instances, for example when combined with MDMA).^[1]

Chemistry edit

DiPT is a derivative of tryptamine formed by substituting isopropyl groups for the two hydrogen atoms attached to the non-aromatic nitrogen atom in the tryptamine molecule.

Pharmacodynamics edit

Binding sites	Binding affinity (K_i, μM)^[2]
5-HT_1A	0.538
5-HT_2A	1.2
5-HT_2C	6.5
D₁	>25
D₂	>25
D₃	>25
α_1A	>12
α_2A	3.6
TAAR₁	>15
H₁	0.92
SERT	0.18
DAT	4.1
NET	8.9

Legal status edit

United Kingdom edit

As is the case with many PiHKAL and TiHKAL drugs, it is Class A in the UK, making it illegal to possess or use.

United States edit

DiPT is not scheduled at the federal level in the United States,^[3] but it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession for human consumption or illicit use that is not for scientific or industrial purposes could be prosecuted under the Federal Analog Act. Some of the people arrested in Operation Web Tryp were selling DiPT, however the drug is not explicitly forbidden or outlawed.

However the US Drug Enforcement Agency (DEA) withdrew a proposal to ban five psychedelic substances including 4-Hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), N-Isopropyl-5-Methoxy-N-Methyltryptamine (5-MeO-MiPT) and N,N-Diisopropyltryptamine (DiPT). DEA withdrew the proposed listing as schedule 1 banned substance after a public hearing in 2022.^[4]

Florida edit

"DiPT (N,N-Diisopropyltryptamine)" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.^[5]

Sweden edit

Sweden's public health agency suggested classifying DiPT as a hazardous substance, on May 15, 2019.^[6]

References edit

^ ^a ^b ^c ^d Shulgin A (1997). TiHKAL: Tryptamines I Have Known and Loved. Berkeley, CA USA: Transform Press. pp. 403–406. ISBN 0-9630096-9-9.
^ Rickli A, Moning OD, Hoener MC, Liechti ME (August 2016). "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens" (PDF). European Neuropsychopharmacology. 26 (8): 1327–37. doi:10.1016/j.euroneuro.2016.05.001. PMID 27216487. S2CID 6685927.
^ "21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I." Drug Enforcement Administration (DEA). U.S. Department Of Justice. Archived from the original on 2009-08-27. Retrieved 2014-12-17.
^ "Placement of 4-hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT), 5-methoxy-N,N-diethyltryptamine (5-MeO-DET), and N,N-diisopropyltryptamine (DiPT) in Schedule I; Withdrawal of Proposed Rule". 27 July 2022.
^ "Chapter 893 - Drug Abuse Prevention and Control". Florida Statutes.
^ "Folkhälsomyndigheten föreslår att 20 ämnen klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 15 May 2019. Archived from the original on 20 October 2021. Retrieved 11 November 2019.