Dibunate

Summary

Dibunate is a cough suppressant.[1] As the sodium salt, it has been marketed under the name Becantyl (in the United Kingdom), Becantex (in continental Europe), or Linctussal with a dosage of 20 to 30 mg, as either syrup or tablets.[2]

Dibunate
Clinical data
Trade namesAducin, Becantal, Becantex, Bechisan, Bexedyl, Keuten, Linctussal, Pectoro
ATC code
Identifiers
  • 2,6-Di-tert-butylnaphthalene-1-sulfonic acid
CAS Number
  • 14992-58-6
PubChem CID
  • 84746
DrugBank
  • DB13796 checkY
ChemSpider
  • 76450 checkY
UNII
  • ZXY319VL5S
KEGG
  • D01700
ChEBI
  • CHEBI:145567
ChEMBL
  • ChEMBL1865134
CompTox Dashboard (EPA)
  • DTXSID7048245 Edit this at Wikidata
ECHA InfoCard100.035.511 Edit this at Wikidata
Chemical and physical data
FormulaC18H24O3S
Molar mass320.45 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=S(=O)(O)c1c2c(ccc1C(C)(C)C)cc(cc2)C(C)(C)C
  • InChI=1S/C18H24O3S/c1-17(2,3)13-8-9-14-12(11-13)7-10-15(18(4,5)6)16(14)22(19,20)21/h7-11H,1-6H3,(H,19,20,21) checkY
  • Key:WBEBQCINXJDZCX-UHFFFAOYSA-N checkY
  (verify)

Similar to benzonatate, it is a peripherally acting drug. It has not been reported to cause sedation, euphoria, habituation, or respiratory depression, unlike narcotic antitussives such as codeine. It may work by blocking afferent signals in the reflex arc which controls cough.[3] Nausea is rarely seen as an adverse effect.[4]

References edit

  1. ^ Sevelius H, Colmore JP (1967). "Antitussive effect of ethyl dibunate in patients with chronic cough". Clinical Pharmacology and Therapeutics. 8 (3): 381–4. doi:10.1002/cpt196783381. PMID 5338382.
  2. ^ "To-day's drugs: Cough suppressants". Br Med J. 1 (5391): 1165-1167. May 2, 1964. PMC 1813498. PMID 14120813.
  3. ^ Simon SW (1957). "A comparative study of two new non-narcotic antitussive drugs". Ohio State Med J. 53 (12): 1426-7. PMID 13493953.
  4. ^ Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 63. ISBN 0-8103-7177-4.