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Dimethyl pimelimidate 
Summary
Dimethyl pimelimidate (DMP) is an organic chemical compound with two functional imidate groups. It is usually available as the more stable dihydrochloride salt. It binds free amino groups at pH range 7.0-10.0 to form amidine bonds.
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| Names | |
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| Preferred IUPAC name
Dimethyl heptanediimidate | |
| Other names
Pimelimidic acid dimethyl ester dihydrochloride,
dimethyl heptane-1,7-diimidate dihydrochloride | |
| Identifiers | |
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3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C9H18N2O2 | |
| Molar mass | 186.255 g·mol−1 |
| Appearance | White crystalline powder (dihydrochloride) |
| Melting point | 122 °C (252 °F; 395 K) dihydrochloride |
| Slightly soluble (dihydrochloride) | |
| Hazards | |
| NFPA 704 (fire diamond) | |
| Flash point | Not determined |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Uses edit
DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.
Health effects edit
DMP is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.
References edit
- MSDS safety data, also available in other languages[permanent dead link]
- Sigma-Aldrich product detail
- MSDS datasheet