Diomede Carafa may refer to:

• Diomede Carafa (died 1487), count of Maddaloni
• Diomede Carafa (cardinal) (1492–1560)
• Diomede Carafa (1520–1561) [it], count of Cerreto and duke of Maddaloni
• Diomede Carafa (died 1572), brother of Pope Paul IV and governor of Castel Sant'Angelo
• Diomede Carafa (bishop of Tricarico) (died 1609)
• Diomede Carafa (1611–1660) [it], count of Cerreto and duke of Maddaloni