Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.[2][3][4] It is marketed in Europe for the treatment of allergies.[2][3][5] DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.[6] It has been shown to be useful in the treatment of Parkinsonism.[7]
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Other names | 4-(diphenylmethoxy)-1-methyl-piperidine |
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Routes of administration | Oral, Topical |
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Elimination half-life | 24–40 hours[1] |
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ECHA InfoCard | 100.005.170 |
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Formula | C19H23NO |
Molar mass | 281.399 g·mol−1 |
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