Donnelley was born in Forest Hills, New York on July 29, 1915. He was a student at Columbia University from 1934 to 1937. During the 1936-37 academic year, he also worked as a junior reporter for the New York Daily News.

In 1937, Donnelley moved to Havana becoming city editor of the Havana Post. He returned to the U.S. in 1941 as assistant city editor of The Washington Daily News. In 1942, he worked as news editor in the Office of the Coordinator of Inter-American Affairs.

After the war, Donnelley spent 1946-47 as press attaché at the United States Embassy in Mexico City. From 1947 to 1948, he was assistant public affairs officer at the U.S. embassy in Santiago, Chile, and was then press attaché at the U.S. embassy in Buenos Aires 1948-49. In 1950, he moved to Washington, D.C. to become an information officer at the United States Department of State focused on the Americas area.

During the 1956 Democratic presidential primaries, Donnelley was the press secretary for Sen. Estes Kefauver (D—TN) to become president of the United States, with Kefauver losing the primaries to Adlai Stevenson.

From 1958 to 1961, Donnelley served as Special Assistant to the Under Secretary of State (Christian Herter and later C. Douglas Dillon). When C. Douglas Dillon was named United States Secretary of the Treasury, Donnelley remained Dillon's assistant, moving with his boss to the United States Department of the Treasury.

In 1966, President Lyndon Johnson nominated Donnelley as Assistant Secretary of State for Public Affairs and Donnelley held this office from March 22, 1966 until January 31, 1969. As such, he was the spokesman of the United States Department of State at the height of the Vietnam War.

• Photo of Dixon Donnelley from Life magazine

• Oral History Interview of Dixon Donnelley at the Miller Center website