Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.
Donna R. Maglott | |
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Alma mater | University of Michigan |
Scientific career | |
Institutions | National Center for Biotechnology Information |
Thesis | The structure and function of the 50S ribosome of Escherichia coli (1970) |
Maglott earned her Ph.D. in 1970 from the University of Michigan where she worked on the 50S ribosome in the bacterium Escherichia coli.[1] She held an academic position at Howard University;[when?] and then moved to the American Type Culture Center in 1986 where she began establishing databases needed for genomic research.[2][3] She started at the National Center for Biotechnology Information (NCBI) in 1998.[4]
While at Howard University, Maglott worked on protein synthesis during early development of sea urchins.[5][6] At ATCC, she worked on repositories holding clone and genomic information[7][8] and began research using genomic tools to investigate information on human chromosomes.[9][10] In 2000, Maglott worked with Kim D. Pruitt to introduce RefSeq, a web-based resource for gene-based information that is hosted by NCBI[11][12] and has been updated over the years.[13][14] She has also been involved in the development of other databases at NCBI including Entrez Gene,[15][16] ClinVar,[17][18] STS markers, Conserved CoDing Sequences (CCDS), Map Viewer, RefSeqGene, the NIH Genetic Testing Registry (GTR), MedGen, and ClinVar.[4] Large-scale genomics projects that Margott has worked on include the rat genome database,[19] and the mouse genome[20][21] and transcriptome.[22] In 2006, Maglott was a part of the team analyzing the genome of the sea urchin, Strongylocentrotus purpuratus, which was the first genome obtained for a motile marine invertebrate.[23][24]