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Dyclonine

Summary

Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge.[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.[2]

Dyclonine
Clinical data
Trade namesSucrets
AHFS/Drugs.comMonograph
Routes of
administration		Lozenge
ATC code
Legal status
Legal status
Identifiers
  • 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
CAS Number
  • 586-60-7 checkY
PubChem CID
  • 3180
IUPHAR/BPS
  • 7173
DrugBank
  • DB00645 checkY
ChemSpider
  • 3068 checkY
UNII
  • 078A24Q30O
KEGG
  • D07881 checkY
ChEBI
  • CHEBI:4724 checkY
ChEMBL
  • ChEMBL1201217 ☒N
CompTox Dashboard (EPA)
  • DTXSID6047864 Edit this at Wikidata
Chemical and physical data
FormulaC18H27NO2
Molar mass289.419 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
  • InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 checkY
  • Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

History edit

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

See also edit

References edit

  1. ^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.
  2. ^ Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.
  3. ^ a b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Archived from the original on 2017-08-22. Retrieved 2011-09-24.
  4. ^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.

External links edit

  • Sucrets: Our heritage