The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.[5]
egf-like module containing, mucin-like, hormone receptor-like 1 | |||||||
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Identifiers | |||||||
Symbol | EMR1 | ||||||
Alt. symbols | TM7LN3 | ||||||
IUPHAR | 182 | ||||||
NCBI gene | 2015 | ||||||
HGNC | 3336 | ||||||
OMIM | 600493 | ||||||
RefSeq | NM_001974 | ||||||
UniProt | Q14246 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.3 | ||||||
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egf-like module containing, mucin-like, hormone receptor-like 2 | |||||||
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Identifiers | |||||||
Symbol | EMR2 | ||||||
IUPHAR | 183 | ||||||
NCBI gene | 30817 | ||||||
HGNC | 3337 | ||||||
OMIM | 606100 | ||||||
RefSeq | NM_152916 | ||||||
UniProt | Q9UHX3 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.1 | ||||||
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egf-like module containing, mucin-like, hormone receptor-like 3 | |||||||
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Identifiers | |||||||
Symbol | EMR3 | ||||||
IUPHAR | 184 | ||||||
NCBI gene | 84658 | ||||||
HGNC | 23647 | ||||||
OMIM | 606101 | ||||||
RefSeq | NM_032571 | ||||||
UniProt | Q9BY15 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.1 | ||||||
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egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene | |||||||
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Identifiers | |||||||
Symbol | EMR4P | ||||||
Alt. symbols | GPR127 | ||||||
NCBI gene | 326342 | ||||||
HGNC | 19240 | ||||||
RefSeq | XM_940358 | ||||||
UniProt | Q86SQ3 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.3 | ||||||
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