BREAKING NEWS
Cloud Server Hosting For Online Businesses
Inexpensive SEO Services
Benefits of Wanting to play Free Online Slot machines
EIF4G3

Summary

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.[5][6] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.[7] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.[8]

EIF4G3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDsOMIM: 603929 MGI: 1923935 HomoloGene: 2789 GeneCards: EIF4G3
Orthologs
SpeciesHumanMouse
Entrez

8672

230861

Ensembl

ENSG00000075151

ENSMUSG00000028760

UniProt

O43432

Q80XI3

RefSeq (mRNA)

NM_001256195
NM_001256198
NM_172703
NM_001355699
NM_001355700

RefSeq (protein)

NP_001185730
NP_001185731
NP_001185732
NP_003751

Location (UCSC)Chr 1: 20.81 – 21.18 MbChr 4: 137.99 – 138.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

EIF4G3 has been shown to interact with PABPC1.[9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075151 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028760 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  6. ^ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
  7. ^ Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
  8. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  9. ^ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

Further reading edit

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Imataka H, Gradi A, Sonenberg N (1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.
  • Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069.
  • Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. doi:10.1128/MCB.19.3.1871. PMC 83980. PMID 10022874.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery". Mol. Cell. 7 (1): 193–203. doi:10.1016/S1097-2765(01)00167-8. PMID 11172724.
  • Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N (2003). "Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different". J. Virol. 77 (8): 5026–9. doi:10.1128/JVI.77.8.5026-5029.2003. PMC 152112. PMID 12663812.
  • Miura T, Shiratori Y, Shimma N (2003). "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII". J. Biomol. NMR. 27 (3): 279–80. doi:10.1023/A:1025442322316. PMID 12975586. S2CID 46050990.
  • Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM (2003). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I". J. Biol. Chem. 278 (49): 48570–9. doi:10.1074/jbc.M308781200. PMID 14507913.
  • Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ (2004). "Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro". J. Virol. 78 (7): 3271–8. doi:10.1128/JVI.78.7.3271-3278.2004. PMC 371048. PMID 15016848.
  • Lejeune F, Ranganathan AC, Maquat LE (2004). "eIF4G is required for the pioneer round of translation in mammalian cells". Nat. Struct. Mol. Biol. 11 (10): 992–1000. doi:10.1038/nsmb824. PMID 15361857. S2CID 3093989.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.