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Encainide

Summary

Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.[1]

Encainide
Clinical data
Trade namesEnkaid
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa605040
ATC code
Legal status
Legal status
  • Withdrawn
Identifiers
  • 4-Methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide
CAS Number
  • 66778-36-7 checkY
PubChem CID
  • 48041
DrugBank
  • DB01228 checkY
ChemSpider
  • 43697 checkY
UNII
  • SY3J0147NB
KEGG
  • D07894 checkY
ChEBI
  • CHEBI:4788 checkY
ChEMBL
  • ChEMBL315838 ☒N
CompTox Dashboard (EPA)
  • DTXSID0022983 Edit this at Wikidata
Chemical and physical data
FormulaC22H28N2O2
Molar mass352.478 g·mol−1
3D model (JSmol)
  • Interactive image
  • COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1
  • InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25) checkY
  • Key:PJWPNDMDCLXCOM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Synthesis edit

 
Synthesis:[2]<

See also edit

References edit

  1. ^ Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. (March 1991). "Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial". The New England Journal of Medicine. 324 (12): 781–8. doi:10.1056/NEJM199103213241201. PMID 1900101.
  2. ^ Dykstra SJ, Minielli JL, Lawson JE, Ferguson HC, Dungan KW (September 1973). "Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines". Journal of Medicinal Chemistry. 16 (9): 1015–20. doi:10.1021/jm00267a012. PMID 4745503.