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Eric J. Nestler

Summary

Eric J. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System.[1][2][3] His research is focused on a molecular approach to drug addiction and depression.

Eric J. Nestler
NationalityAmerican
Alma mater
Scientific career
FieldsMolecular neurobiology
Molecular neuropharmacology
Clinical neuroscience
Institutions

He is the co-author of four books and more than 725 peer-reviewed articles, and he serves as principal investigator or co-principal investigator on 8 NIH grants.

Biography edit

Education edit

Nestler is a graduate of Herricks High School in New Hyde Park, New York. He received his B.A., his Ph.D. and his M.D. from Yale University, where he performed his doctoral research in the laboratory of Paul Greengard. He completed his residency in psychiatry at both McLean Hospital in Massachusetts and Yale in 1987.[1]

Career edit

Nestler served as Director of the Abraham Ribicoff Research Facilities, as the Founding Director of the Division of Molecular Psychiatry at Yale until 2000, and as Chairman of the Department of Psychiatry at the University of Texas Southwestern Medical Center at Dallas.[1] He joined Mount Sinai in 2008. He has served on the Boards of Scientific Counselors of the National Institute on Drug Abuse and of the National Institute on Alcohol Abuse and Alcoholism, on the National Advisory Mental Health Council for the National Institute of Mental Health, the National Advisory Drug Abuse Council for the National Institute on Drug Abuse,[4] as Council Member of the American College of Neuropsychopharmacology (for which he served as president in 2011) and the Society for Neuroscience (for which he served as president in 2017). He is a member of the Scientific Advisory Board of the Brain & Behavior Research Foundation (BBRF, previously NARSAD) and of One Mind (previously International Mental Health Research Organization),[5] as well as a past member of the Board of Directors of the McKnight Endowment Fund in Neuroscience.[6] He was elected to the Institute of Medicine (now National Academy of Medicine) in 1998 and the American Academy of Arts and Sciences in 2005.[6][7]

Research edit

The Nestler laboratory's focus in neuropsychopharmacology and molecular neuroscience concentrates on forming a molecular approach to psychiatry and furthering the understanding of the molecular basis of both depression and drug addiction, using animal models to study the way drug use or stress affects the brain.[1] His addiction research largely centers around several transcription factors, including ΔFosB and CREB (master control proteins that induce addiction or depression in vulnerable individuals or resistance to these syndromes in resilient individuals) and the associated epigenetic remodeling that occurs in specific neuronal or glial cell types in the brain. A major goal is to identify the ‘chromatin scars’—long lasting epigenetic changes at specific genomic loci—that mediate lifelong changes in disease vulnerability. Among the prominent targets of this work are medium spiny neurons of the nucleus accumbens and pyramidal neurons in prefrontal cortex and ventral hippocampus.[3][8][9] The Nestler laboratory has driven innovative use of viral-mediated gene transfer, inducible, cell-type specific mutations in mice, and locus-specific epigenome editing to establish causal links between molecular and behavioral phenomena in animal models.[8][9][10] The laboratory also makes creative use of advanced machine learning approaches to derive novel biological insight from large sequencing datasets.

Awards edit

Dr. Nestler's awards and honors include the Pfizer Scholars Award (1987), the Sloan Research Fellowship (1987), the McKnight Scholar Award (1989), the Jordi-Folch-Pi Memorial Award from the American Society of Neurochemistry (1990), the Efron Award of the American College of Neuropsychopharmacology (1994), the Pasarow Foundation Award for Neuropsychiatric Research (1998), the NARSAD Distinguished Investigator Award (1996), the Bristol-Myers Squibb Freedom to Discover Neuroscience Research Grant (2004), the Patricia S. Goldman-Rakic Award and the Falcone Prize both from NARSAD (2008, 2009),[11] and the Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine (2010). He received an honorary doctorate from Uppsala University in Sweden in 2011, and the Anna Monika Prize in Depression Research (2012).[12][13]

In 2017, he was awarded the Wilbur Cross Medal by Yale University[14] for distinguished alumnus from the graduate school, and the Paul Hoch Distinguished Service Award from the American College of Neuropsychopharmacology.[15] In 2019, he received the Redelsheimer Distinguished Award in Biological Psychiatry from the Society for Biological Psychiatry. In 2020, Dr. Nestler received an honorary degree from Concordia University in Montreal as “a pioneer in depression and drug-addiction research and institutional advocacy for equity, diversity and inclusion. He is also the recipient of the Barbara Fish Memorial Award in 2021 for outstanding contributions to the field of neuroscience from the American College of Neuropsychopharmacology and the Peter Seeburg Integrative Neuroscience Prize in 2023 from the Schaller-Nikolich Foundation and Society for Neuroscience.

NIH-Funded Grants and Research edit

Role Source, Title Identifier
Principal Investigator NIDA, Transcriptional Mechanisms of Drug Addiction[16] P01 DA047233
Principal Investigator NIMH, Pharmacological Actions of Stress & Antidepressants Treatments[17] R01 MH51399
Principal Investigator NIDA, Role of Neurotrophic Factors in the Actions of Drugs of Abuse[18] R01 DA14133
Principal Investigator NIDA, Molecular Studies of Cocaine Action in Brain[19] R01 DA07359
Principal Investigator NIMH, Pharmacological Actions of Stress & Antidepressants Treatments R01 MH51399
Principal Investigator NIMH, Epigenetic Mechanisms of Chronic Stress Action R01 MH129306
Co-Principal Investigator NIDA, Small Molecule Modulators of ∆FosB Function R01 DA040621
Co-Principal Investigator NIDA, Glial-Mediated Synaptic Remodeling in Drug Addiction R01 DA040620

Publications (partial list) edit

Books edit

Nestler is the author (with Dennis S. Charney, Pamela Sklar and Joseph D. Buxbaum) of Neurobiology of Mental Illness (5th edition; ISBN 0195189809), of Nestler, Hyman and Malenka’s Molecular Neuropharmacology (with Paul J. Kenny, Scott J. Russo and Anne Schaefer); 4th edition; ISBN 978-1-26045-690-5) and two additional books published earlier: Protein Phosphorylation in the Nervous System (with Paul Greengard; ISBN 978-0-47180-558-8) and Molecular Foundations of Psychiatry (with Steven E. Hyman; ISBN 978-0-88048-353-7). He is also the author of more than 725 peer-reviewed publications and reviews.[20] He directs six research projects funded by the National Institute on Drug Abuse and the National Institute of Mental Health. He also serves as director of the Depression Task Force of the Hope for Depression Research Foundation.

Articles edit

Nestler has been cited more than 134,000 times and has an H-index of 188.[21][20]

  • Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ (2016). "Circuit-wide transcriptional profiling reveals brain region-specific gene networks regulating depression susceptibility". Neuron. 90 (5): 969–83. doi:10.1016/j.neuron.2016.04.015. PMC 4896746. PMID 27181059.
  • Berton O, McClung CA, DiLeone RJ, Krishnan V, Russo S, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ (2006). "Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress". Science. 311 (5762): 864–868. Bibcode:2006Sci...311..864B. doi:10.1126/science.1120972. PMID 16469931. S2CID 32965598.
  • Browne CJ, Futamura R, Minier-Toribio A, Hicks EM, Ramakrishnan A, Martínez-Rivera FJ, Estill M, Godino A, Parise EM, Torres-Berrío A, Cunningham AM, Hamilton PJ, Walker DM, Huckins LM, Hurd YL, Shen L, Nestler EJ (2023). "Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice". Sci Adv. 9 (23). Bibcode:2023SciA....9G8558B. doi:10.1126/sciadv.adg8558. PMC 10256172. PMID 37294757.
  • Cahill ME, Bagot RC, Gancarz AM, Walker DM, Sun H, Wang ZJ, Heller EA, Feng J, Kennedy PJ, Koo JW, Cates HM, Neve RL, Shen L, Dietz DM, Nestler EJ (2016). "Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling". Neuron. 89 (3): 566–582. doi:10.1016/j.neuron.2016.01.031. PMC 4743039. PMID 26844834.
  • Carlezon WA, Boundy VA, Haile CN, Kalb RG, Neve R, Nestler EJ (1997). "Sensitization to morphine induced by viral-mediated gene transfer". Science. 277 (5327): 812–814. doi:10.1126/science.277.5327.812. PMID 9242609.
  • Carlezon WA, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998). "Regulation of cocaine reward by CREB". Science. 282 (5397): 2272–2275. Bibcode:1998Sci...282.2272C. doi:10.1126/science.282.5397.2272. PMID 9856954.
  • Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ (2014). "β-catenin mediates stress resilience through Dicer1/microRNA regulation". Nature. 516 (7529): 51–55. Bibcode:2014Natur.516...51D. doi:10.1038/nature13976. PMC 4257892. PMID 25383518.
  • Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ (2015). "Role of Tet1 and 5-hydroxymethylcytosine in cocaine action". Nat Neurosci. 18 (4): 536–444. doi:10.1038/nn.3976. PMC 4617315. PMID 25774451.
  • Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, Browne CJ, Mews P, Hamilton PJ, Neve RL, Shen L, Russo SJ, Nestler EJ (2023). "Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards". Neuron. 111 (9): 1453–1467. doi:10.1016/j.neuron.2023.02.013. PMC 10164098. PMID 36889314.
  • Heller EA, Cates HM, Peña CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ (2014). "Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors". Nat Neurosci. 17 (12): 1720–1727. doi:10.1038/nn.3871. PMC 4241193. PMID 25347353.
  • Issler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, Kronman H, Duffy JE, Estill MS, Calipari ES, Labonté B, Neve RL, Tamminga CA, Brennand KJ, Dong Y, Shen L, Nestler EJ (2020). "Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression". Neuron. 106 (6): 912–926.e5. doi:10.1016/j.neuron.2020.03.023. PMC 7305959. PMID 32304628.
  • Issler O, van der Zee YY, Ramakrishnan A, Xia S, Zinsmaier AK, Tan C, Li W, Browne CJ, Walker DM, Salery M, Torres-Berrío A, Futamura R, Duffy JE, Labonte B, Girgenti MJ, Tamminga CA, Dupree JL, Dong Y, Murrough JW, Shen L, Nestler EJ (2022). "The long noncoding RNA FEDORA is a cell type- and sex-specific regulator of depression". Sci Adv. 8 (48). Bibcode:2022SciA....8N9494I. doi:10.1126/sciadv.abn9494. PMC 9710883. PMID 36449610.
  • Kelz MB, Chen JS, Carlezon WA, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch R, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ (1999). "Expression of the transcription factor ∆FosB in the brain controls sensitivity to cocaine". Nature. 401 (6750): 272–276. doi:10.1038/45790. PMID 10499584. S2CID 4390717.
  • Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun HS, Scobie K, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo KM, Neve RL, Russo SJ, Han MH, Nestler EJ (2012). "Novel role of BDNF as a negative modulator of morphine action". Science. 338 (6103): 124–128. doi:10.1126/science.1222265. PMC 3547365. PMID 23042896.
  • Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ (2015). "Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area". Nat Neurosci. 18 (3): 415–422. doi:10.1038/nn.3932. PMC 4340719. PMID 25643298.
  • Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ (2007). "Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions". Cell. 131 (2): 391–404. doi:10.1016/j.cell.2007.09.018. PMID 17956738.
  • Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM, van der Zee YY, Browne CJ, Boyce BF, Neve R, Garcia BA, Shen L, Peña CJ, Nestler EJ (2021). "Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons". Nat Neurosci. 24 (5): 667–676. doi:10.1038/s41593-021-00814-8. PMC 8216773. PMID 33723435.
  • Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, Laplant Q, Sasaki TS, Whistler KN, Neve RL, Self DW, Nestler EJ (2005). "Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum". Neuron. 48 (2): 303–314. doi:10.1016/j.neuron.2005.09.023. PMID 16242410.
  • Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic AL, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ (2017). "Sex-specific transcriptional signatures in human depression". Nat Med. 23 (9): 1102–1111. doi:10.1038/nm.4386. PMC 5734943. PMID 28825715.
  • Lobo MK, Covington HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ (2010). "Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward". Science. 330 (6002): 385–390. Bibcode:2010Sci...330..385L. doi:10.1126/science.1188472. PMC 3011229. PMID 20947769.
  • Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, Labonté B, Conkey A, Symonds AE, Neve RL, Turecki G, Maze I, Dong Y, Zhang B, Shen L, Bagot RC, Nestler EJ (2019). "Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex". Nat Neurosci. 22 (9): 1413–1423. doi:10.1038/s41593-019-0462-8. PMC 6713580. PMID 31427770.
  • Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren YH, Sampath SC, Hurd YL, Greengard P, Tarakovsky A, Schaefer A, Nestler EJ (2010). "Essential role of the histone methyltransferase G9a in cocaine-induced plasticity". Science. 327 (5962): 213–216. Bibcode:2010Sci...327..213M. doi:10.1126/science.1179438. PMC 2820240. PMID 20056891.
  • Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ (2014). "Analytical tools and current challenges in the modern era of neuroepigenomics". Nat Neurosci. 17 (11): 1476–1490. doi:10.1038/nn.3816. PMC 4262187. PMID 25349914.
  • McClung CA, Nestler EJ (2003). "Regulation of gene expression and cocaine reward by CREB and ∆FosB". Nature Neuroscience. 6 (11): 1208–1215. doi:10.1038/nn1143. PMID 14566342. S2CID 38115726.
  • Mews P, Cunningham AM, Scarpa J, Ramakrishnan A, Hicks EM, Bolnick S, Garamszegi S, Shen L, Mash DC, Nestler EJ (2023). "Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards". Sci Adv. 9 (6). doi:10.1126/sciadv.add8946. PMC 9916993. PMID 36763659.
  • Nectow AR, Nestler EJ (2020). "Viral tools for neuroscience". Nature Reviews Neuroscience. 21 (12): 669–681. doi:10.1038/s41583-020-00382-z. PMC 7808553. PMID 33110222.
  • Nestler EJ, Aghajanian GK (1997). "Molecular and cellular basis of addiction". Science. 278 (5335): 58–63. doi:10.1126/science.278.5335.58. PMID 9311927.
  • Nestler EJ (2001). "Molecular basis of long-term plasticity underlying addiction". Nat Rev Neurosci. 2 (2): 119–128. doi:10.1038/35053570. PMID 11252991. S2CID 52849205.
  • Peña CJ, Kronman HG, Walker DM, Cates HM, Bagot RC, Purushothaman I, Issler O, Loh YE, Leong T, Kiraly DD, Goodman E, Neve RL, Shen L, Nestler EJ (2017). "Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2". Science. 356 (6343): 1185–1188. doi:10.1126/science.aan4491. PMC 5539403. PMID 28619944.
  • Renthal W, Kumar A, Xiao GH, Wilkinson M, Convington HE, Mze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ (2009). "Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins". Neuron. 62 (3): 335–348. doi:10.1016/j.neuron.2009.03.026. PMC 2779727. PMID 19447090.
  • Robison AJ, Nestler EJ (2011). "Transcriptional and epigenetic mechanisms of addiction". Nat. Rev. Neurosci. 12 (11): 623–637. doi:10.1038/nrn3111. PMC 3272277. PMID 21989194.
  • Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal WR, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ (2007). "The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates". Nature Neuroscience. 10 (1): 93–99. doi:10.1038/nn1812. PMID 17143271. S2CID 2887841.
  • Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R (2000). "Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis". Nature Medicine. 6 (9): 985–990. doi:10.1038/79683. PMID 10973317. S2CID 20302360.
  • Self DW, Barnhart WJ, Lehman DA, Nestler EJ (1996). "Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists". Science. 271 (5255): 1586–1589. doi:10.1126/science.271.5255.1586. PMID 8599115. S2CID 38774917.
  • Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Koo JW, Korb E, Bagot RC, Ahn FH, Cahill ME, Labonté B, Mouzon E, Heller EA, Cates H, Golden SA, Gleason K, Russo SJ, Andrews S, Neve R, Kennedy PJ, Maze I, Dietz DM, Allis CD, Turecki G, Varga-Weisz P, Tamminga C, Shen L, Nestler EJ (2015). "ACF Chromatin-Remodeling Complex Mediates Stress-Induced Depressive-Like Behavior". Nat Med. 21 (10): 1146–1153. doi:10.1038/nm.3939. PMC 4598281. PMID 26390241.
  • Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006). "Sustained hippocampal chromatin regulation in hippocampus in a mouse model of depression and antidepressant action". Nature Neuroscience. 9 (4): 519–525. doi:10.1038/nn1659. PMID 16501568. S2CID 21547891.
  • Vialou V, Robison AJ, LaPlant QC, Covington HE, Dietz DM, Ohnishi YN, Mouzon E, Rush AJ, Watts EL, Wallace DL, Iñiguez SD, Ohnishi YH, Steiner MA, Warren B, Krishnan V, Neve RL, Ghose S, Berton O, Tamminga CA, Nestler EJ (2010). "∆FosB in brain reward circuits mediates resilience to stress and antidepressant responses". Nature Neuroscience. 13 (6): 745–752. doi:10.1038/nn.2551. PMC 2895556. PMID 20473292.
  • Yim, YY, et al. (2020). "In vivo locus-specific editing of the neuroepigenome". Nature Reviews Neuroscience. 21 (9): 471–484. doi:10.1038/s41583-020-0334-y. PMC 7439525. PMID 32704051.

References edit

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  3. ^ a b "Mount Sinai's Eric Nestler headlining first of new lecture series hosted by School of Neuroscience". www.neuroscience.vt.edu. Retrieved 2020-05-24.
  4. ^ "National Institute on Drug Abuse". Archived from the original on 14 July 2014. Retrieved 9 June 2014.
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  6. ^ a b "The McKnight Endowment Fund for Neuroscience". Retrieved 9 June 2014.
  7. ^ "Center for Brain Health". Archived from the original on 4 March 2016. Retrieved 9 June 2014.
  8. ^ a b Whalley K (December 2014). "Psychiatric disorders: a feat of epigenetic engineering". Nat. Rev. Neurosci. 15 (12): 768–769. doi:10.1038/nrn3869. PMID 25409693. Chronic exposure to stress or drugs of abuse causes widespread changes in the activity of chromatin remodelling enzymes. However, it has been difficult to determine the relative functional importance of drug- or stress-induced epigenetic modifications of individual genes. Nestler and colleagues have now employed gene- and brain-region-specific chromatin remodelling to examine the role of one particular gene, [ΔFosB], in addiction- and depression-related changes in the brain and behaviour. ... This study shows that single epigenetic modifications can modulate both [ΔFosB] expression and its behavioural effects. A similar approach may be used to target other genes of interest and elucidate further the changes in molecular pathways that underlie psychiatric disorders.
  9. ^ a b Heller, Elizabeth A; et al. (2014). "Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors". Nature Neuroscience. 17 (12): 1720–1727. doi:10.1038/nn.3871. ISSN 1097-6256. PMC 4241193. PMID 25347353.
  10. ^ Dennis S. Charney (2003). "Preface". In Charney, Dennis S. (ed.). Molecular neurobiology for the clinician. Washington, DC: American Psychiatric Pub. pp. xvi–xvii. ISBN 9781585627332. Dr. Nestler, in Chapter 4, presents an extremely creative and potentially groundbreaking view of the molecular mechanisms and neural circuitry of reward and how they might relate to vulnerability to addictive behaviors. ... Dr. Nestler focuses on two transcription factors, CREB (cAMP response element binding protein) and ΔFosB
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  13. ^ "New York Social Diary". 2008-10-23. Archived from the original on 10 July 2014. Retrieved 9 June 2014.
  14. ^ "Yale Graduate School honors four alumni with Wilbur Cross Medals". Archived from the original on 11 October 2022. Retrieved 3 January 2017.
  15. ^ "Eric Nestler given the ACNP Paul Hoch Distinguished Service Award". Archived from the original on 4 January 2018. Retrieved 3 January 2017.
  16. ^ Nestler EJ (2001). "Molecular neurobiology of addiction". Am J Addict. 10 (3): 201–17. doi:10.1080/105504901750532094. PMID 11579619.
  17. ^ Malberg JE, Eisch AJ, Nestler EJ, Duman RS (December 2000). "Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus". J. Neurosci. 20 (24): 9104–10. doi:10.1523/JNEUROSCI.20-24-09104.2000. PMC 6773038. PMID 11124987.
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  21. ^ "Eric Nestler - Google Scholar Citations". scholar.google.com. Retrieved 2020-05-23.

External links edit

  • Nestler Lab at the Icahn School of Medicine

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