Escort destroyer (DDE) is a US Navy post World War II classification for destroyers (DD) modified for and assigned to escort fleets.

Escort destroyer may also refer to:

• Hunt-class destroyer, a class of destroyers of the Royal Navy designed to escort convoys
• River-class destroyer escort, a class of escort destroyers operated by the Royal Australian Navy
• V and W-class destroyer, a grouping of similar classes of Royal Navy First World War destroyers used for convoy escort in the Second World War
• F-class escort ship, a class of fleet escorts used by the Kriegsmarine during the Second World War
• Matsu-class destroyer escort destroyers built by the Imperial Japanese Navy not intended to work with the fleet
• Tachibana-class destroyer escort destroyers built by the Imperial Japanese Navy not intended to work with the fleet