European route E272 is a Class B road part of the International E-road network. It runs only through Lithuania, begins in Klaipėda and ends in Vilnius.

E272
Major junctions
From	Klaipėda
To	Vilnius
Location
Countries	Lithuania
Major cities	Klaipėda Palanga Šiauliai Panevėžys Ukmergė Vilnius
Highway system
International E-road network A Class B Class

Route: Klaipėda - Palanga - Šiauliai - Panevėžys - Ukmerge - Vilnius.

From Klaipėda to Palanga it follows the route of Lithuanian highway A13, A11 from Palanga to Šiauliai, A9 from Šiauliai to Panevėžys, A17 just outside Panevėžys and A2 from Panevėžys to Vilnius.