FOXF1 Knowpia

FOXF1
Identifiers
Aliases	FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1
External IDs	OMIM: 601089 MGI: 1347470 HomoloGene: 1114 GeneCards: FOXF1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	86,515,422 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,814,883 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right lung; ; lower lobe of lung; ; urinary bladder; ; mucosa of urinary bladder; ; upper lobe of lung; ; upper lobe of left lung; ; pylorus; ; fundus; ; urethra;
	Top expressed in
	right lung lobe; ; left lung lobe; ; molar; ; somatopleuric mesenchyme; ; urinary bladder; ; yolk sac; ; abdominal wall; ; sclerotome; ; allantois; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus;
Biological process	somitogenesis; regulation of smooth muscle cell differentiation; renal system development; ureter development; regulation of transcription, DNA-templated; lung morphogenesis; embryonic foregut morphogenesis; lung development; positive regulation of cell migration; endocardial cushion development; cellular response to organic cyclic compound; extracellular matrix organization; cardiac left ventricle morphogenesis; in utero embryonic development; negative regulation of transcription by RNA polymerase II; negative regulation of mast cell degranulation; smooth muscle cell differentiation; morphogenesis of a branching structure; venous blood vessel development; cellular response to cytokine stimulus; right lung morphogenesis; transcription, DNA-templated; vasculogenesis; positive regulation of transcription, DNA-templated; respiratory tube development; heart development; determination of left/right symmetry; establishment of epithelial cell apical/basal polarity; blood vessel development; embryonic ectodermal digestive tract morphogenesis; positive regulation of mesenchymal cell proliferation; embryonic digestive tract morphogenesis; animal organ morphogenesis; pancreas development; detection of wounding; mesenchyme migration; smoothened signaling pathway; lateral mesodermal cell differentiation; lung alveolus development; digestive tract development; lung vasculature development; mesoderm development; epithelial tube branching involved in lung morphogenesis; negative regulation of inflammatory response; lung lobe morphogenesis; ductus arteriosus closure; embryonic digestive tract development; positive regulation of transcription by RNA polymerase II; epithelial cell differentiation involved in mammary gland alveolus development; midgut development; positive regulation of cell-substrate adhesion; transcription by RNA polymerase II; cell differentiation; cell-cell adhesion; trachea development;
	Sources:Amigo / QuickGO
Orthologs
	2294
	15227
	ENSG00000103241
	ENSMUSG00000042812
	Q12946
	Q61080
	NM_001451
	NM_010426
	NP_001442
	NP_034556
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene.^[5]^[6]^[7]

Function edit

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
^ "Entrez Gene: FOXF1 forkhead box F1".
^ "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.

External links edit

FOXF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103241 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8825632-5] Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.

[pmid7957066-6] Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.

[entrez-7] "Entrez Gene: FOXF1 forkhead box F1".

[8] "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

Summary

Function edit

References edit

Further reading edit

External links edit